Synthesis of a 2-deoxy-ribose type 1-N-iminosugar

被引：38

作者：

Makino, K ^{[1
]}

Ichikawa, Y ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 45期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)01781-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 2-deoxy-ribose-type 1-N-iminosugar 5 was synthesized, in multi-gram scale, from fumaric acid monoethyl ester employing Sharpless asymmetric epoxidation followed by a Lewis acid-catalyzed (Yamamoto's aluminum reagent) cyanide epoxy ring-opening reactions. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8245 / 8248

页数：4

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