Neocentromeres: New insights into centromere structure, disease development, and karyotype evolution

被引：286

作者：

Marshall, Owen J. ^{[1
,2
]}

Chueh, Anderly C. ^{[1
,2
]}

Wong, Lee H. ^{[1
,2
]}

Choo, K. H. Andy ^{[1
,2
]}

机构：

[1] Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2008年 / 82卷 / 02期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/j.ajhg.2007.11.009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Since the discovery of the first human neocentromere in 1993, these spontaneous, ectopic centromeres have been shown to be an astonishing example of epigenetic change within the genome. Recent research has focused on the role of neocentromeres in evolution and speciation, as well as in disease development and the understanding of the organization and epigenetic maintenance of the centromere. Here, we review recent progress in these areas of research and the significant insights gained.

引用

页码：261 / 282

页数：22

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