Brain/MINDS: brain-mapping project in Japan

被引:108
作者
Okano, Hideyuki [1 ,3 ]
Miyawaki, Atsushi [2 ]
Kasai, Kiyoto [4 ]
机构
[1] Brain Sci Inst RIKEN, Lab Marmoset Neural Architecture, Wako, Saitama 3510198, Japan
[2] Brain Sci Inst RIKEN, Lab Cell Funct Dynam, Wako, Saitama 3510198, Japan
[3] Keio Univ, Sch Med, Dept Physiol, Shinjuku Ku, Tokyo 1608582, Japan
[4] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan
关键词
brain mapping by integrated neurotechnologies for disease studies; transgenic non-human primates; optogenetics; tissue clearing; super-resolution microscopy; neuropsychiatric and neurodegenerative diseases; NEUROSCIENCE RESEARCH; FLUORESCENT PROTEIN; COMMON MARMOSET; WHITE-MATTER; MOUSE-BRAIN; SCHIZOPHRENIA; VOLUME; INTACT; TISSUE; GRAY;
D O I
10.1098/rstb.2014.0310
中图分类号
Q [生物科学];
学科分类号
090105 [作物生产系统与生态工程];
摘要
There is an emerging interest in brain-mapping projects in countries across the world, including the USA, Europe, Australia and China. In 2014, Japan started a brain-mapping project called Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Brain/MINDS aims to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain, and takes advantage of a unique non-human primate animal model, the common marmoset (Callithrix jacchus). In Brain/MINDS, the RIKEN Brain Science Institute acts as a central institute. The objectives of Brain/MINDS can be categorized into the following three major subject areas: (i) structure and functional mapping of a non-human primate brain (the marmoset brain); (ii) development of innovative neurotechnologies for brain mapping; and (iii) human brain mapping; and clinical research. Brain/MINDS researchers are highly motivated to identify the neuronal circuits responsible for the phenotype of neurological and psychiatric disorders, and to understand the development of these devastating disorders through the integration of these three subject areas.
引用
收藏
页码:33 / 41
页数:9
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