Mutations in katG, inhA and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis

被引：91

作者：

Silva, MSN

Senna, SG

Ribeiro, MO

Valim, ARM

Telles, MA

Kritski, A

Morlock, GP

Cooksey, RC

Zaha, A

Rossetti, MLR

机构：

[1] Fundacao Estadual Prod & Pesquisa Saude, CDCT, Lab Cent Saude Publ, BR-90610000 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande Sul, Ctr Biotecnol, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande Sul, Dept Biol Mol & Biotecnol, Porto Alegre, RS, Brazil

[4] Inst Adolfo Lutz Registro, Setor Micobacterias, Sao Paulo, Brazil

[5] Univ Fed Rio de Janeiro, Hosp Clementino Fraga Filho, Inst Doencas Torax, Rio De Janeiro, Brazil

[6] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div AIDS STD & TB Lab Res, Atlanta, GA USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2003年 / 41卷 / 09期

关键词：

D O I：

10.1128/JCM.41.9.4471-4474.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The presence of mutations in specific regions of the katG, inhA, and ahpC genes was analyzed with 69 Mycobacterium tuberculosis isoniazid-resistant isolates from three Brazilian states. Point mutations in codon 315 of the katG gene were observed in 87.1, 60.9, and 60% of the isolates from Rio Grande do Sul, Rio de Janeiro, and Sao Paulo, respectively. Mutations in the inhA gene were identified only in one isolate from RJ State, and the ahpC promoter region revealed mutations in distinct positions in 12.9, 21.7, and 6.7% of the isolates from RS, RJ and SP, respectively.

引用

页码：4471 / 4474

页数：4

共 29 条

[1] Variations in the occurrence of the S315T mutation within the katG gene in isoniazid-resistant clinical Mycobacterium tuberculosis isolates from Kuwait [J].