A mathematical model describing the thermal virus inactivation

被引：6

作者：

Noël, C ^{[1
]}

Charles, S ^{[1
]}

Francon, A ^{[1
]}

Flandrois, JP ^{[1
]}

机构：

[1] Aventis Pasteur, Dept Dev, F-69280 Marcy Letoile, France

来源：

VACCINE | 2001年 / 19卷 / 25-26期

关键词：

kinetic; mathematical model; oral polymyelitis vaccine; temperature; thermal inactivation; viral vaccines;

D O I：

10.1016/S0264-410X(01)00011-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A new mathematical model is proposed to describe the inactivation of viruses at different temperatures. This model takes into account the exponential decrease of the viral titer with time, the inactivation rate being an exponential function of the temperature. A one-step non-linear regression was used to fit oral poliovirus vaccine (OPV) experimental data. In one of the applications of the model, we illustrate the use of our model to compare the accelerated degradation test of OPV new formulations to standard OPV. Such a model is both simple and convenient to use. It should be a useful tool in optimizing formulations for live viral vaccines. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3575 / 3582

页数：8

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