Palladium-Catalyzed β Arylation of Carboxylic Esters

被引：151

作者：

Renaudat, Alice ^{[2
]}

Jean-Gerard, Ludivine ^{[2
]}

Jazzar, Rodolphe ^{[2
]}

Kefalidis, Christos E. ^{[1
]}

Clot, Eric ^{[1
]}

Baudoin, Olivier ^{[2
]}

机构：

[1] Univ Montpellier 2, Inst Charles Gerhardt, UMR 5253, F-34000 Montpellier, France

[2] Univ Lyon 1, Inst Chim & Biochim Mol & Supramol, CPE Lyon, CNRS,UMR 5246, F-69622 Villeurbanne, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 40期

关键词：

arylation; C-C coupling; C-H functionalization; esters; palladium; C-H BONDS; CARBONYL-COMPOUNDS; ORGANIC-SYNTHESIS; ALPHA-ARYLATION; ARYL HALIDES; FUNCTIONALIZATION; ACTIVATION; ACIDS; SP(2);

D O I：

10.1002/anie.201003544

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Alter ego: In the presence of an appropriate palladium(0) catalyst, carboxylic esters underwent β arylation instead of the more common α-arylation reaction with aryl halides containing an ortho electronegative substituent (see scheme; Cy = cyclohexyl). An asymmetric version of the reaction gave the product with an enantiomeric ratio of up to 77:23. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7261 / 7265

页数：5

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