Synergistic effects of tamoxifen and cepharanthine for circumventing the multidrug resistance

被引：11

作者：

Hotta, T ^{[1
]}

Tanimura, H ^{[1
]}

Yamaue, H ^{[1
]}

Iwahashi, M ^{[1
]}

Tani, M ^{[1
]}

Tsunoda, T ^{[1
]}

Noguchi, K ^{[1
]}

Mizobata, S ^{[1
]}

Terasawa, H ^{[1
]}

机构：

[1] WAKAYAMA SCH MED,DEPT SURG 2,WAKAYAMA 640,JAPAN

来源：

CANCER LETTERS | 1996年 / 107卷 / 01期

关键词：

multidrug resistance; P-glycoprotein; doxorubicin; tamoxifen; cepharanthine;

D O I：

10.1016/0304-3835(96)04358-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the synergistic effects of tamoxifen (TAM) and cepharanthine (CEP) for doxorubicin (DOX) sensitivity using MTT assay. The augmentation of DOX sensitivity by TAM and CEP was significantly correlated with the P-glycoprotein expression. The cytotoxic effect of DOX with TAM and CEP was significantly higher than that of DOX alone, or DOX with TAM, and this synergistic effect was dominant in cell lines with high expression of P-glycoprotein. It was also examined that the intracellular concentration of DOX was increased in combined exposure of TAM and CEP, compared with the exposure of TAM, because TAM and CEP promoted the influx and inhibited the efflux of DOX. Thus, TAM and CEP might be able to circumvent DOX-resistance for treatment in cancer patients.

引用

页码：117 / 123

页数：7

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[2]

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