Mammalian stanniocalcins and cancer

被引：146

作者：

Chang, ACM ^{[1
]}

Jellinek, DA ^{[1
]}

Reddel, RR ^{[1
]}

机构：

[1] Childrens Med Res Inst, Canc Res Unit, Westmead, NSW 2145, Australia

来源：

关键词：

HORMONE-RELATED PROTEIN; DIFFERENTIAL GENE-EXPRESSION; HUMAN BREAST-CANCER; PARATHYROID-HORMONE; STANNIUS CORPUSCLES; MESSENGER-RNA; OVARIAN STANNIOCALCIN; ESTROGEN-RECEPTOR; MOLECULAR-CLONING; RAINBOW-TROUT;

D O I：

10.1677/erc.0.0100359

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stanniocalcin (STC) is a glycoprotein hormone that is secreted by the corpuscle of Stannius, an endocrine gland of bony fish, and is involved in calcium and phosphate homeostasis. The related mammalian proteins, STC1 and STC2, are expressed in a wide variety of tissues. The ovaries have the highest level of STC1, and this increases during pregnancy and lactation. STC1 is present in breast ductal epithelium, and its expression is induced by BRCA1, a tumor suppressor gene that has an important role in breast and ovarian cancer. The expression of STC2 is induced by estrogen, and there is a positive correlation between the level of expression of estrogen receptor and expression of both STC1 and STC2 in breast cancer. This article reviews the data currently available regarding the mammalian STCs, and discusses the roles they may play in normal physiology and in breast and other cancers.

引用

页码：359 / 373

页数：15

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