Chitin and chitosan activate complement via the alternative pathway

被引:66
作者
Minami, S [1 ]
Suzuki, H
Okamoto, Y
Fujinaga, T
Shigemasa, Y
机构
[1] Tottori Univ, Fac Agr, Dept Vet Surg, Tottori 6808553, Japan
[2] Hokkaido Univ, Grad Sch Vet Med, Dept Vet Clin Sci, Lab Vet Surg, Sapporo, Hokkaido 0600818, Japan
[3] Tottori Univ, Fac Engn, Dept Mat Sci, Tottori 6808552, Japan
关键词
chitin; chitosan; alternative pathway;
D O I
10.1016/S0144-8617(98)00015-0
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The effect of chitosan on the serum C3 concentration was investigated in dogs and mice after subcutaneous administration. Chitosan (10 mg/kg) induced an increase of the C3 level in dogs, but not in mice. To attain the same C3 level in mice as in dogs, the dose of chitosan had to be increased five-fold. Chitin and chitosan activated complement components C3 and C5, but not C4. The intensity of complement activation was greater with chitosan than with chitin. Chitin and chitosan both activated complement via the alternative pathway. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:151 / 155
页数:5
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