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Biochemistry - A pore way to die
被引:214
作者
:
Halestrap, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Sch Med Sci, Bristol Heart Inst, Bristol BS8 1TD, Avon, England
Univ Bristol, Sch Med Sci, Bristol Heart Inst, Bristol BS8 1TD, Avon, England
Halestrap, A
[
1
]
机构
:
[1]
Univ Bristol, Sch Med Sci, Bristol Heart Inst, Bristol BS8 1TD, Avon, England
[2]
Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England
来源
:
NATURE
|
2005年
/ 434卷
/ 7033期
关键词
:
D O I
:
10.1038/434578a
中图分类号
:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号
:
07 ;
0710 ;
09 ;
摘要
:
Like Jekyll to Hyde, mitochondria can change from acting as the cell's powerhouses to become merciless killers. Mice lacking this mechanism develop normally, and their hearts are resistant to pathological damage.
引用
收藏
页码:578 / 579
页数:2
相关论文
共 12 条
[1]
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
[J].
Baines, CP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Baines, CP
;
Kaiser, RA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Kaiser, RA
;
Purcell, NH
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Purcell, NH
;
Blair, NS
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Blair, NS
;
Osinska, H
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Osinska, H
;
Hambleton, MA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Hambleton, MA
;
Brunskill, EW
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Brunskill, EW
;
Sayen, MR
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Sayen, MR
;
Gottlieb, RA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Gottlieb, RA
;
Dorn, GW
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Dorn, GW
;
Robbins, J
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Robbins, J
;
Molkentin, JD
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Molkentin, JD
.
NATURE,
2005,
434
(7033)
:658
-662
[2]
A mitochondrial perspective on cell death
[J].
Bernardi, P
论文数:
0
引用数:
0
h-index:
0
机构:
Dept Biomed Sci, I-35121 Padua, Italy
Bernardi, P
;
Petronilli, V
论文数:
0
引用数:
0
h-index:
0
机构:
Dept Biomed Sci, I-35121 Padua, Italy
Petronilli, V
;
Di Lisa, F
论文数:
0
引用数:
0
h-index:
0
机构:
Dept Biomed Sci, I-35121 Padua, Italy
Di Lisa, F
;
Forte, M
论文数:
0
引用数:
0
h-index:
0
机构:
Dept Biomed Sci, I-35121 Padua, Italy
Forte, M
.
TRENDS IN BIOCHEMICAL SCIENCES,
2001,
26
(02)
:112
-117
[3]
CROMPTON M, 1988, BIOCHEM J, V255, P357
[4]
The pathophysiology of mitochondrial cell death
[J].
Green, DR
论文数:
0
引用数:
0
h-index:
0
机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Green, DR
;
Kroemer, G
论文数:
0
引用数:
0
h-index:
0
机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Kroemer, G
.
SCIENCE,
2004,
305
(5684)
:626
-629
[5]
Biochemistry - A pore way to die
[J].
Halestrap, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Sch Med Sci, Bristol Heart Inst, Bristol BS8 1TD, Avon, England
Univ Bristol, Sch Med Sci, Bristol Heart Inst, Bristol BS8 1TD, Avon, England
Halestrap, A
.
NATURE,
2005,
434
(7033)
:578
-579
[6]
Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection
[J].
Halestrap, AP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Halestrap, AP
;
Clarke, SJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Clarke, SJ
;
Javadov, SA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Javadov, SA
.
CARDIOVASCULAR RESEARCH,
2004,
61
(03)
:372
-385
[7]
The permeability transition pore complex: another view
[J].
Halestrap, AP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Halestrap, AP
;
McStay, GP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
McStay, GP
;
Clarke, SJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Clarke, SJ
.
BIOCHIMIE,
2002,
84
(2-3)
:153
-166
[8]
Role of mitochondrial membrane permeabilization in apoptosis and cancer
[J].
Henry-Mowatt, J
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
Henry-Mowatt, J
;
Dive, C
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
Dive, C
;
Martinou, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
Martinou, JC
;
James, D
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
James, D
.
ONCOGENE,
2004,
23
(16)
:2850
-2860
[9]
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
[J].
Kokoszka, JE
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Kokoszka, JE
;
Waymire, KG
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Waymire, KG
;
Levy, SE
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Levy, SE
;
Sligh, JE
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Sligh, JE
;
Cal, JY
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Cal, JY
;
Jones, DP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Jones, DP
;
MacGregor, GR
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
MacGregor, GR
;
Wallace, DC
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Wallace, DC
.
NATURE,
2004,
427
(6973)
:461
-465
[10]
Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis
[J].
Li, YM
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Li, YM
;
Johnson, N
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Johnson, N
;
Capano, M
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Capano, M
;
Edwards, M
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Edwards, M
;
Crompton, M
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Crompton, M
.
BIOCHEMICAL JOURNAL,
2004,
383
:101
-109
←
1
2
→
共 12 条
[1]
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
[J].
Baines, CP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Baines, CP
;
Kaiser, RA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Kaiser, RA
;
Purcell, NH
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Purcell, NH
;
Blair, NS
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Blair, NS
;
Osinska, H
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Osinska, H
;
Hambleton, MA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Hambleton, MA
;
Brunskill, EW
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Brunskill, EW
;
Sayen, MR
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Sayen, MR
;
Gottlieb, RA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Gottlieb, RA
;
Dorn, GW
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Dorn, GW
;
Robbins, J
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Robbins, J
;
Molkentin, JD
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Univ Cincinnati, Childrens Hosp, Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA
Molkentin, JD
.
NATURE,
2005,
434
(7033)
:658
-662
[2]
A mitochondrial perspective on cell death
[J].
Bernardi, P
论文数:
0
引用数:
0
h-index:
0
机构:
Dept Biomed Sci, I-35121 Padua, Italy
Bernardi, P
;
Petronilli, V
论文数:
0
引用数:
0
h-index:
0
机构:
Dept Biomed Sci, I-35121 Padua, Italy
Petronilli, V
;
Di Lisa, F
论文数:
0
引用数:
0
h-index:
0
机构:
Dept Biomed Sci, I-35121 Padua, Italy
Di Lisa, F
;
Forte, M
论文数:
0
引用数:
0
h-index:
0
机构:
Dept Biomed Sci, I-35121 Padua, Italy
Forte, M
.
TRENDS IN BIOCHEMICAL SCIENCES,
2001,
26
(02)
:112
-117
[3]
CROMPTON M, 1988, BIOCHEM J, V255, P357
[4]
The pathophysiology of mitochondrial cell death
[J].
Green, DR
论文数:
0
引用数:
0
h-index:
0
机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Green, DR
;
Kroemer, G
论文数:
0
引用数:
0
h-index:
0
机构:
La Jolla Inst Allergy & Immunol, Div Cellular Immunol, San Diego, CA 92121 USA
Kroemer, G
.
SCIENCE,
2004,
305
(5684)
:626
-629
[5]
Biochemistry - A pore way to die
[J].
Halestrap, A
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Sch Med Sci, Bristol Heart Inst, Bristol BS8 1TD, Avon, England
Univ Bristol, Sch Med Sci, Bristol Heart Inst, Bristol BS8 1TD, Avon, England
Halestrap, A
.
NATURE,
2005,
434
(7033)
:578
-579
[6]
Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection
[J].
Halestrap, AP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Halestrap, AP
;
Clarke, SJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Clarke, SJ
;
Javadov, SA
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Javadov, SA
.
CARDIOVASCULAR RESEARCH,
2004,
61
(03)
:372
-385
[7]
The permeability transition pore complex: another view
[J].
Halestrap, AP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Halestrap, AP
;
McStay, GP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
McStay, GP
;
Clarke, SJ
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Univ Bristol, Dept Biochem, Bristol BS8 1TD, Avon, England
Clarke, SJ
.
BIOCHIMIE,
2002,
84
(2-3)
:153
-166
[8]
Role of mitochondrial membrane permeabilization in apoptosis and cancer
[J].
Henry-Mowatt, J
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
Henry-Mowatt, J
;
Dive, C
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
Dive, C
;
Martinou, JC
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
Martinou, JC
;
James, D
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
James, D
.
ONCOGENE,
2004,
23
(16)
:2850
-2860
[9]
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
[J].
Kokoszka, JE
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Kokoszka, JE
;
Waymire, KG
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Waymire, KG
;
Levy, SE
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Levy, SE
;
Sligh, JE
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Sligh, JE
;
Cal, JY
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Cal, JY
;
Jones, DP
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Jones, DP
;
MacGregor, GR
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
MacGregor, GR
;
Wallace, DC
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA
Wallace, DC
.
NATURE,
2004,
427
(6973)
:461
-465
[10]
Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis
[J].
Li, YM
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Li, YM
;
Johnson, N
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Johnson, N
;
Capano, M
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Capano, M
;
Edwards, M
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Edwards, M
;
Crompton, M
论文数:
0
引用数:
0
h-index:
0
机构:
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
Crompton, M
.
BIOCHEMICAL JOURNAL,
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