Biochemistry - A pore way to die

被引:214
作者
Halestrap, A [1 ]
机构
[1] Univ Bristol, Sch Med Sci, Bristol Heart Inst, Bristol BS8 1TD, Avon, England
[2] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England
关键词
D O I
10.1038/434578a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Like Jekyll to Hyde, mitochondria can change from acting as the cell's powerhouses to become merciless killers. Mice lacking this mechanism develop normally, and their hearts are resistant to pathological damage.
引用
收藏
页码:578 / 579
页数:2
相关论文
共 12 条
[1]   Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death [J].
Baines, CP ;
Kaiser, RA ;
Purcell, NH ;
Blair, NS ;
Osinska, H ;
Hambleton, MA ;
Brunskill, EW ;
Sayen, MR ;
Gottlieb, RA ;
Dorn, GW ;
Robbins, J ;
Molkentin, JD .
NATURE, 2005, 434 (7033) :658-662
[2]   A mitochondrial perspective on cell death [J].
Bernardi, P ;
Petronilli, V ;
Di Lisa, F ;
Forte, M .
TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (02) :112-117
[3]  
CROMPTON M, 1988, BIOCHEM J, V255, P357
[4]   The pathophysiology of mitochondrial cell death [J].
Green, DR ;
Kroemer, G .
SCIENCE, 2004, 305 (5684) :626-629
[5]   Biochemistry - A pore way to die [J].
Halestrap, A .
NATURE, 2005, 434 (7033) :578-579
[6]   Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection [J].
Halestrap, AP ;
Clarke, SJ ;
Javadov, SA .
CARDIOVASCULAR RESEARCH, 2004, 61 (03) :372-385
[7]   The permeability transition pore complex: another view [J].
Halestrap, AP ;
McStay, GP ;
Clarke, SJ .
BIOCHIMIE, 2002, 84 (2-3) :153-166
[8]   Role of mitochondrial membrane permeabilization in apoptosis and cancer [J].
Henry-Mowatt, J ;
Dive, C ;
Martinou, JC ;
James, D .
ONCOGENE, 2004, 23 (16) :2850-2860
[9]   The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore [J].
Kokoszka, JE ;
Waymire, KG ;
Levy, SE ;
Sligh, JE ;
Cal, JY ;
Jones, DP ;
MacGregor, GR ;
Wallace, DC .
NATURE, 2004, 427 (6973) :461-465
[10]   Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis [J].
Li, YM ;
Johnson, N ;
Capano, M ;
Edwards, M ;
Crompton, M .
BIOCHEMICAL JOURNAL, 2004, 383 :101-109