Inherited thrombophilia: Impact on human reproduction

被引：45

作者：

Buchholz, T ^{[1
]}

Thaler, CJ ^{[1
]}

机构：

[1] Univ Munich, LMU Hosp Grosshadern, Dept Obstet & Gynecol, Munich, Germany

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2003年 / 50卷 / 01期

关键词：

fibrinolysis; hemostasis; placental perfusion; pregnancy;

D O I：

10.1034/j.1600-0897.2003.00049.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of thrombotic disorders is a major threat for young women during pregnancy. It is one of the main causes of pregnancy-related disorders, which may also result in harm for the conceptus. Successful pregnancies require an even balance of coagulation and fibrinolysis, in order to secure stabilization of the basal plate as well as adequate placental perfusion. Thrombophilia is a laboratory definition for pre-disposing factors of thrombosis, which can be inherited or acquired. Many individuals, who carry a thrombotic defect remain asymptomatic, at least until additional boosting factors arise. The, documentation of thrombophilic causes of recurrent miscarriage or pregnancy-related disorders is important, because of availability of effective early treatment. There is a rapidly growing awareness on the relationship of genetic factors influencing hemostasis and pregnancy-related disorders. The aim of our review is to summarize this knowledge, focusing on common genetic variations.

引用

页码：20 / 32

页数：13

共 107 条

[21] Association of a common polymorphism in the factor XIII gene with venous thrombosis [J].

Catto, AJ ;

Kohler, HP ;

Coore, J ;

Mansfield, MW ;

Stickland, MH ;

Grant, PJ .

BLOOD, 1999, 93 (03) :906-908

[22]

Chrobak L, 1998, Vnitr Lek, V44, P481

[23] Structure/function analysis of human factor XII using recombinant deletion mutants - Evidence for an additional region involved in the binding to negatively charged surfaces [J].

Citarella, F ;

Ravon, DM ;

Pascucci, B ;

Felici, A ;

Fantoni, A ;

Hack, CE .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 238 (01) :240-249

[24] THE 5' SEQUENCE OF HUMAN FACTOR-XII GENE CONTAINS TRANSCRIPTION REGULATORY ELEMENTS TYPICAL OF LIVER SPECIFIC, ESTROGEN-MODULATED GENES [J].

CITARELLA, F ;

MISITI, S ;

FELICI, A ;

AIUTI, A ;

LAPORTA, C ;

FANTONI, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1172 (1-2) :197-199

[25]

Clark P, 1998, THROMB HAEMOSTASIS, V79, P1166

[26] Haemostatic and metabolic abnormalities in women with unexplained recurrent abortion [J].

Coumans, ABC ;

Huijgens, PC ;

Jakobs, C ;

Schats, R ;

de Vries, JIP ;

van Pampus, MG ;

Dekker, GA .

HUMAN REPRODUCTION, 1999, 14 (01) :211-214

[27]

Dahlback B, 1996, HAEMOSTASIS, V26, P301

[28] FAMILIAL THROMBOPHILIA DUE TO A PREVIOUSLY UNRECOGNIZED MECHANISM CHARACTERIZED BY POOR ANTICOAGULANT RESPONSE TO ACTIVATED PROTEIN-C - PREDICTION OF A COFACTOR TO ACTIVATED PROTEIN-C [J].

DAHLBACK, B ;

CARLSSON, M ;

SVENSSON, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (03) :1004-1008

[29] GENETIC-VARIATION AT THE PLASMINOGEN-ACTIVATOR INHIBITOR-1 LOCUS IS ASSOCIATED WITH ALTERED LEVELS OF PLASMA PLASMINOGEN-ACTIVATOR INHIBITOR-1 ACTIVITY [J].

DAWSON, S ;

HAMSTEN, A ;

WIMAN, B ;

HENNEY, A ;

HUMPHRIES, S .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (01) :183-190

[30]

DAWSON SJ, 1993, J BIOL CHEM, V268, P10739

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