Toll-like receptors and dendritic cells: for whom the bug tolls

被引：253

作者：

Sousa, CRE ^{[1
]}

机构：

[1] London Res Inst, Immunobiol Lab, Canc Res UK, Lincolns Inn Fields Labs, London WC2A 3PX, England

来源：

SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 01期

关键词：

dendritic cells; toll-like receptors; innate recognition; co-stimulation; cytokines;

D O I：

10.1016/j.smim.2003.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recognition of molecular signatures of potential pathogens via toll-like receptors (TLRs) activates dendritic cells (DC), leading to the initiation of adaptive immunity. TLR signalling in DC causes an increase in display of MHC peptide ligands for T cell recognition, upregulation of co-stimulatory molecules important for T cell clonal expansion and secretion of immunomodulatory cytokines, which direct T cell differentiation into effectors. Remarkably, ligation of distinct TLRs can trigger differential cytokine production in a single DC type or result in different cytokines in distinct DC sub-types. Studying the complexity of DC responses to TLR ligands illuminates the link between innate recognition and adaptive immunity, paving the way for improved vaccines and strategies to induce tolerance to autoantigens or allografts. (C) 2003 Elsevier Ltd. All rights reserved.

引用

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页码：27 / 34

页数：8

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