Sensitive optical biosensors for unlabeled targets: A review

被引：1660

作者：

Fan, Xudong ^{[1
]}

White, Ian M. ^{[1
]}

Shopova, Siyka I. ^{[1
]}

Zhu, Hongying ^{[1
]}

Suter, Jonathan D. ^{[1
]}

Sun, Yuze ^{[1
]}

机构：

[1] Univ Missouri, Dept Biol Engn, Columbia, MO 65211 USA

来源：

ANALYTICA CHIMICA ACTA | 2008年 / 620卷 / 1-2期

关键词：

optical biosensor; photonic biosensor; label-free; refractive index;

D O I：

10.1016/j.aca.2008.05.022

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This article reviews the recent progress in optical biosensors that use the label-free detection protocol, in which biomolecules are unlabeled or unmodified, and are detected in their natural forms. in particular, it will focus on the optical biosensors that utilize the refractive index change as the sensing transduction signal. Various optical label-free biosensing platforms will be introduced, including, but not limited to, surface plasmon resonance, interferometers, waveguides, fiber gratings, ring resonators, and photonic crystals. Emphasis will be given to the description of optical structures and their respective sensing mechanisms. Examples of detecting various types of biomolecules will be presented. Wherever possible, the sensing performance of each optical structure will be evaluated and compared in terms of sensitivity and detection limit. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：8 / 26

页数：19

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