Microwave-assisted solid-phase Ugi four-component condensations

被引：85

作者：

Hoel, AML ^{[1
]}

Nielsen, J ^{[1
]}

机构：

[1] Tech Univ Denmark, Dept Organ Chem, DK-2800 Lyngby, Denmark

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 20期

关键词：

solid-phase synthesis; Ugi-Passerini reactions; microwave heating; combinatorial chemistry;

D O I：

10.1016/S0040-4039(99)00616-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An 18-member library was constructed from 2 isocyanides, 3 aldehydes and 3 carboxylic acids via microwave-assisted solid-phase Ugi reactions on TentaGel S RAM. Products of high purity were obtained in moderate to excellent yields after reaction times of 5 minutes or less (irradiation at 60W). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3941 / 3944

页数：4

共 26 条

[1] Multiple-component condensation strategies for combinatorial library synthesis [J].

Armstrong, RW ;

Combs, AP ;

Tempest, PA ;

Brown, SD ;

Keating, TA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :123-131

[2] Microwave assisted combinatorial chemistry synthesis of substituted pyridines [J].

Cotterill, IC ;

Usyatinsky, AY ;

Arnold, JM ;

Clark, DS ;

Dordick, JS ;

Michels, PC ;

Khmelnitsky, YL .

TETRAHEDRON LETTERS, 1998, 39 (10) :1117-1120

[3]

Dömling A, 1998, COMB CHEM HIGH T SCR, V1, P1

[4] Dielectric parameters relevant to microwave dielectric heating [J].

Gabriel, C ;

Gabriel, S ;

Grant, EH ;

Halstead, BSJ ;

Mingos, DMP .

CHEMICAL SOCIETY REVIEWS, 1998, 27 (03) :213-223

[5] Synthesis of small and medium sized 2,2-disubstituted lactams via the ''intramolecular'' three component Ugi reaction [J].

Harriman, GCB .

TETRAHEDRON LETTERS, 1997, 38 (32) :5591-5594

[6] The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: Novel application of Armstrong's convertible isonitrile. [J].

Hulme, C ;

Morrissette, MM ;

Volz, FA ;

Burns, CJ .

TETRAHEDRON LETTERS, 1998, 39 (10) :1113-1116

[7] Improved procedure for the solution phase preparation of 1,4-benzodiazepine-2,5-dione libraries via Armstrong's convertible isonitrile and the Ugi reaction [J].

Hulme, C ;

Peng, J ;

Tang, SY ;

Burns, CJ ;

Morize, I ;

Labaudiniere, R .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (22) :8021-8023

[8] A remarkable two-step synthesis of diverse 1,4-benzodiazepine-2,5-diones using the Ugi four-component condensation [J].

Keating, TA ;

Armstrong, RW .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (25) :8935-8939

[9] Multicomponent solution phase synthesis of dehydroamino acid derivatives based on the Passerini reaction [J].

Kim, SW ;

Bauer, SM ;

Armstrong, RW .

TETRAHEDRON LETTERS, 1998, 39 (39) :7031-7034

[10] Construction of combinatorial chemical libraries using a rapid and efficient solid phase synthesis based on a multicomponent condensation reaction [J].

Kim, SW ;

Bauer, SM ;

Armstrong, RW .

TETRAHEDRON LETTERS, 1998, 39 (39) :6993-6996

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