Plants as a source of anti-cancer agents

被引：1368

作者：

Cragg, GM ^{[1
]}

Newman, DJ ^{[1
]}

机构：

[1] NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21702 USA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 100卷 / 1-2期

关键词：

camptothecins; combretastatins; flavopiridol; podophyllotoxins; taxanes; vinca alkaloids; cell cycle target inhibitor;

D O I：

10.1016/j.jep.2005.05.011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Plant-derived compounds have been an important source of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide. derived froth epipodophyllotoxin, and paclitaxel (taxol(R)). A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：72 / 79

页数：8

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