Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

被引：524

作者：

Dessaud, Eric ^{[2
]}

McMahon, Andrew P. ^{[1
]}

Briscoe, James ^{[2
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Natl Inst Med Res, London NW7 1AA, England

来源：

DEVELOPMENT | 2008年 / 135卷 / 15期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1242/dev.009324

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neuronal subtype specification in the vertebrate neural tube is one of the best-studied examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a precise spatial order from progenitor cells according to their location along the anterior-posterior and dorsal-ventral axes. Underpinning this organization is a complex network of multiple extrinsic and intrinsic factors. This review focuses on the molecular mechanisms and general strategies at play in ventral regions of the forming spinal cord, where sonic hedgehog-based morphogen signaling is a key determinant. We discuss recent advances in our understanding of these events and highlight unresolved questions.

引用

页码：2489 / 2503

页数：15

共 118 条

[1] Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site [J].

Ågren, M ;

Kogerman, P ;

Kleman, MI ;

Wessling, M ;

Toftgård, R .

GENE, 2004, 330 :101-114

[2] The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal [J].

Alcedo, J ;

Ayzenzon, M ;

VonOhlen, T ;

Noll, M ;

Hooper, JE .

CELL, 1996, 86 (02) :221-232

[3] The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development [J].

Allen, Benjamin L. ;

Tenzen, Toyoaki ;

McMahon, Andrew P. .

GENES & DEVELOPMENT, 2007, 21 (10) :1244-1257

[4] Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression [J].

Alvarez-Medina, Roberto ;

Cayuso, Jordi ;

Okubo, Tadashi ;

Takada, Shinji ;

Marti, Elisa .

DEVELOPMENT, 2008, 135 (02) :237-247

[5] All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3 [J].

Bai, CB ;

Stephen, D ;

Joyner, AL .

DEVELOPMENTAL CELL, 2004, 6 (01) :103-115

[6] A global genomic transcriptional code associated with CNS-expressed genes [J].

Bailey, Peter J. ;

Klos, Joanna M. ;

Andersson, Elisabet ;

Karlen, Mattias ;

Kallstrom, Magdalena ;

Ponjavic, Jasmina ;

Muhr, Jonas ;

Lenhard, Boris ;

Sandelin, Albin ;

Ericson, Johan .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (16) :3108-3119

[7] Repression of smoothened by patched-dependent (Pro-)Vitamin D3 secretion [J].

Bijlsma, Maarten F. ;

Spek, C. Arnold ;

Zivkovic, Danica ;

van de Water, Sandra ;

Rezaee, Farhad ;

Peppelenbosch, Maikel P. .

PLOS BIOLOGY, 2006, 4 (08) :1397-1410

[8] Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord [J].

Bourikas, D ;

Pekarik, V ;

Baeriswyl, T ;

Grunditz, Å ;

Sadhu, R ;

Nardó, M ;

Stoeckli, ET .

NATURE NEUROSCIENCE, 2005, 8 (03) :297-304

[9] Specification of neuronal fates in the ventral neural tube [J].

Briscoe, J ;

Ericson, J .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (01) :43-49

[10] Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling [J].

Briscoe, J ;

Sussel, L ;

Serup, P ;

Hartigan-O'Connor, D ;

Jessell, TM ;

Rubenstein, JLR ;

Ericson, J .

NATURE, 1999, 398 (6728) :622-627

← 1 2 3 4 5 6 7 8 9 10 →