Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

被引：536

作者：

Dessaud, Eric ^{[2
]}

McMahon, Andrew P. ^{[1
]}

Briscoe, James ^{[2
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Natl Inst Med Res, London NW7 1AA, England

来源：

DEVELOPMENT | 2008年 / 135卷 / 15期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1242/dev.009324

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neuronal subtype specification in the vertebrate neural tube is one of the best-studied examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a precise spatial order from progenitor cells according to their location along the anterior-posterior and dorsal-ventral axes. Underpinning this organization is a complex network of multiple extrinsic and intrinsic factors. This review focuses on the molecular mechanisms and general strategies at play in ventral regions of the forming spinal cord, where sonic hedgehog-based morphogen signaling is a key determinant. We discuss recent advances in our understanding of these events and highlight unresolved questions.

引用

页码：2489 / 2503

页数：15

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