An alternative approach to the synthesis of functionalized pyrido[2,3-b]indoles

被引：32

作者：

Beccalli, EM ^{[1
]}

Clerici, F ^{[1
]}

Marchesini, A ^{[1
]}

机构：

[1] Univ Milan, Fac Farm, Ist Chim Organ, I-20133 Milan, Italy

来源：

TETRAHEDRON | 2001年 / 57卷 / 22期

关键词：

alpha-carbolines; enamines; oxindoles; thermal cyclization;

D O I：

10.1016/S0040-4020(01)00404-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of alpha -carbolines was developed starting from the easily accessible 3-substituted indol-2(3H)-one derivatives 2 and enamines 3. The intermediates 4 afforded the a-carbolines 5 and 6 by thermal cyclization with ammonium acetate in glacial acetic acid by way of pyridine ring formation. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4787 / 4792

页数：6

共 20 条

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