Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

被引：1143

作者：

Chen, Qian ^{[1
]}

Feng, Liangzhu ^{[1
]}

Liu, Jingjing ^{[1
]}

Zhu, Wenwen ^{[1
]}

Dong, Ziliang ^{[1
]}

Wu, Yifan ^{[1
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 33期

基金：

中国国家自然科学基金;

关键词：

GUIDED PHOTOTHERMAL THERAPY; CANCER-THERAPY; PHOTODYNAMIC THERAPY; PROTEIN CAPSULES; DRUG-DELIVERY; SOLID TUMORS; IN-VIVO; PENETRATION; OXYGEN; CELLS;

D O I：

10.1002/adma.201601902

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A unique type of pH/H2O2 dual-responsive intelligent nanoscale delivery system based on albumin-coated MnO2 is presented, which is capable of modulating the tumor microenvironment (TME) by relieving hypoxia. Additionally, TME-responsive size changes enable effective intratumor diffusion. A highly effective combined photodynamic and chemotherapy is realized with these nanoparticles in a mouse tumor model.

引用

收藏

页码：7129 / +

页数：9

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