Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy

被引：771

作者：

Fan, Wenpei ^{[1
]}

Bu, Wenbo ^{[1
,2
]}

Shen, Bo ^{[3
]}

He, Qianjun ^{[1
]}

Cui, Zhaowen ^{[1
]}

Liu, Yanyan ^{[1
]}

Zheng, Xiangpeng ^{[4
]}

Zhao, Kuaile ^{[5
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Nanjing Tech Univ, Jiangsu Collaborat Innovat Ctr Adv Inorgan Funct, Nanjing 210009, Jiangsu, Peoples R China

[3] Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China

[4] Fudan Univ, Shanghai Huadong Hosp, Dept Radiat Oncol, Shanghai 200040, Peoples R China

[5] Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 28期

基金：

中国国家自然科学基金;

关键词：

MnO2; nanosheets; synergetic therapy; tumor oxygenation; upconversion luminescen imaging; upconversion nanoprobes; PHOTODYNAMIC THERAPY; HYDROGEN-PEROXIDE; DRUG-DELIVERY; TUMOR HYPOXIA; QUANTUM DOTS; IRON-OXIDE; NANOPARTICLES; GRAPHENE; CANCER; RADIATION;

D O I：

10.1002/adma.201405141

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Intelligent 2D theranostic nanomaterials are successfully designed based on pH-/H2O2-responsive MnO2 nanosheets anchored with upconversion nanoprobes. They react with acidic H2O2 to generate sufficient oxygen for enhancing the synergetic radio/photodynamic therapy efficacy upon NIR light/X-ray irradiation and recover/enhance the upconversion luminescence for monitoring the therapeutic process. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：4155 / 4161

页数：7

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