Complex regional pain syndrome

被引:140
作者
Birklein, F [1 ]
机构
[1] Univ Mainz, Neurol Klin, D-55101 Mainz, Germany
关键词
complex regional pain syndrome (CRPS); sympathetically maintained pain (SMP); neurogenic inflammation; neuroplasticity; physical therapy;
D O I
10.1007/s00415-005-0737-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Complex regional pain syndrome (CRPS) may develop after limb trauma and is characterized by pain, sensory-motor and autonomic symptoms. Most important for the understanding of the pathophysiology of CRPS are recent results of neurophysiological research. Major mechanism for CRPS symptoms, which might be present subsequently or in parallel during the course of CRPS, are trauma-related cytokine release, exaggerated neurogenic inflammation, sympathetically maintained pain and cortical reorganisation in response to chronic pain (neuroplasticity). The recognition of these mechanisms in individual CRPS patients is the prerequisite for a mechanism-oriented treatment.
引用
收藏
页码:131 / 138
页数:8
相关论文
共 67 条
[1]   Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain [J].
Ali, Z ;
Raja, SN ;
Wesselmann, U ;
Fuchs, PN ;
Meyer, RA ;
Campbell, JN .
PAIN, 2000, 88 (02) :161-168
[2]   LACK OF ANALGESIC EFFECT OF OPIOIDS ON NEUROPATHIC AND IDIOPATHIC FORMS OF PAIN [J].
ARNER, S ;
MEYERSON, BA .
PAIN, 1988, 33 (01) :11-23
[3]   INCREASED VENOUS ALPHA-ADRENOCEPTOR RESPONSIVENESS IN PATIENTS WITH REFLEX SYMPATHETIC DYSTROPHY [J].
ARNOLD, JMO ;
TEASELL, RW ;
MACLEOD, AP ;
BROWN, JE ;
CARRUTHERS, SG .
ANNALS OF INTERNAL MEDICINE, 1993, 118 (08) :619-621
[4]   Substance P antagonists: the next breakthrough in treating depression? [J].
Baby, S ;
Nguyen, M ;
Tran, D ;
Raffa, RB .
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 1999, 24 (06) :461-469
[5]   Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study [J].
Baron, R ;
Schattschneider, J ;
Binder, A ;
Siebrecht, D ;
Wasner, G .
LANCET, 2002, 359 (9318) :1655-1660
[6]   Increased skin lactate in complex regional pain syndrome:: Evidence for tissue hypoxia? [J].
Birklein, F ;
Weber, M ;
Neundörfer, B .
NEUROLOGY, 2000, 55 (08) :1213-1215
[7]   Pattern of autonomic dysfunction in time course of complex regional pain syndrome [J].
Birklein, F ;
Riedl, B ;
Claus, D ;
Neundorfer, B .
CLINICAL AUTONOMIC RESEARCH, 1998, 8 (02) :79-85
[8]   Neurological findings in complex regional pain syndromes -: analysis of 145 cases [J].
Birklein, F ;
Riedl, B ;
Sieweke, N ;
Weber, M ;
Neundörfer, B .
ACTA NEUROLOGICA SCANDINAVICA, 2000, 101 (04) :262-269
[9]   The important role of neuropeptides in complex regional pain syndrome [J].
Birklein, F ;
Schmelz, M ;
Schifter, S ;
Weber, M .
NEUROLOGY, 2001, 57 (12) :2179-2184
[10]   Sudomotor function in sympathetic reflex dystrophy [J].
Birklein, F ;
Sittl, R ;
Spitzer, A ;
Claus, D ;
Neundorfer, B ;
Handwerker, HO .
PAIN, 1997, 69 (1-2) :49-54