Synaptic Mechanisms Underlying Sparse Coding of Active Touch

被引:194
作者
Crochet, Sylvain [1 ,2 ]
Poulet, James F. A. [1 ,3 ,4 ]
Kremer, Yves [1 ]
Petersen, Carl C. H. [1 ]
机构
[1] Ecole Polytech Fed Lausanne, Fac Life Sci, Brain Mind Inst, Lab Sensory Proc, CH-1015 Lausanne, Switzerland
[2] CNRS, Lyon Neurosci Res Ctr, Integrat Physiol Brain Arousal Syst UMR5292, INSERM,U1028, F-69500 Bron, France
[3] Max Delbruck Ctr Mol Med, Dept Neurosci, D-10392 Berlin, Germany
[4] Charite, Neurocure Neurosci Res Ctr, D-10117 Berlin, Germany
基金
瑞士国家科学基金会;
关键词
RAT BARREL CORTEX; PRIMARY SOMATOSENSORY CORTEX; THALAMOCORTICAL FEEDFORWARD INHIBITION; SENSORY RESPONSES; BEHAVING MICE; TACTILE DISCRIMINATION; SENSORIMOTOR SYSTEM; OBJECT LOCALIZATION; NEURONAL-ACTIVITY; RECEPTIVE-FIELDS;
D O I
10.1016/j.neuron.2011.02.022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sensory information is actively gathered by animals, but the synaptic mechanisms driving neuronal circuit function during active sensory processing are poorly understood. Here, we investigated the synaptically driven membrane potential dynamics during active whisker sensation using whole-cell recordings from layer 2/3 pyramidal neurons in the primary somatosensory barrel cortex of behaving mice. Although whisker contact with an object evoked rapid depolarization in all neurons, these touch responses only drove action potentials in similar to 10% of the cells. Such sparse coding was ensured by cell-specific reversal potentials of the touch-evoked response that were hyperpolarized relative to action potential threshold for most neurons. Intercontact interval profoundly influenced touch-evoked postsynaptic potentials, interestingly without affecting the peak membrane potential of the touch response. Dual whole-cell recordings indicated highly correlated membrane potential dynamics during active touch. Sparse action potential firing within synchronized cortical layer 2/3 microcircuits therefore appears to robustly signal each active touch response.
引用
收藏
页码:1160 / 1175
页数:16
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