1,3-dipolar cycloaddition: Click chemistry for the synthesis of 5-substituted tetrazoles from organoaluminum azides and nitriles

被引：155

作者：

Aureggi, Valentina ^{[1
]}

Sedelmeier, Gottfried ^{[1
]}

机构：

[1] Novartis Pharma AG, Chem & Analyt Dev, CH-4057 Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 44期

关键词：

azides; cycloaddition; nitriles; sartans; tetrazoles;

D O I：

10.1002/anie.200701045

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cheap and safe: Conventional methods to prepare tetrazoles employ dangerous, toxic reagents. A new route to these heterocycles (see scheme) uses inexpensive and nontoxic dialkyl aluminum azides. The cycloaddition occurs under mild conditions and tolerates a variety of functional groups. The low cost and ecocompatibility make this process attractive for large-scale preparation. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8440 / 8444

页数：5

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