GLYCOSIDES FROM VALLARIS SOLANACEAE WITH TRAIL-RESISTANCE-OVERCOMING ACTIVITY

被引：12

作者：

Ahmed, Firoj ^{[1
]}

Sadhu, Samir Kumar ^{[1
,2
]}

Ohtsuki, Takashi ^{[1
]}

Khatun, Amina ^{[2
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

[2] Khulna Univ, Sch Life Sci, Pharm Discipline, Khulna 9208, Bangladesh

来源：

HETEROCYCLES | 2010年 / 80卷 / 01期

基金：

日本学术振兴会;

关键词：

Glycoside; Vallaris solanaceae; Cytotoxicity; TRAIL; CERBERA-MANGHAS; DIE GLYKOSIDE; UP-REGULATION; CANCER-CELLS; LUNG-CANCER; APOPTOSIS; CARDENOLIDES; ACTIVATION; CYTOTOXICITY; MECHANISMS;

D O I：

10.3987/COM-09-S(S)52

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new cardenolide glycoside, vallarisoside (1), and a known one, 3 beta-O-(alpha-acofriosyl)-l6-anhydrogitoxigenin (2) along with a new glycoside, benzyl 2-O-beta-apiofuranosyl-(1 -> 2)-beta-D-glucopyranosyl-2, 6-dihydroxy-benzoate (3) were isolated from Vallaris solanaceae. Structures of the isolates were elucidated by 1D and 2D NMR and mass spectroscopic analysis. Of the isolates, vallarisoside (1) showed potent TRAIL-resistance-overcoming activity in human gastric adenocarcinoma (AGS) cells and cell-growth-inhibitory activity against HeLa and SW480 cells.

引用

页码：477 / 488

页数：12

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