fastsimcoal: a continuous-time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios

被引：343

作者：

Excoffier, Laurent ^{[1
,2
]}

Foll, Matthieu ^{[1
,2
]}

机构：

[1] Univ Bern, Inst Ecol & Evolut, CH-3012 Bern, Switzerland

[2] Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

来源：

BIOINFORMATICS | 2011年 / 27卷 / 09期

关键词：

APPROXIMATE BAYESIAN COMPUTATION; DEMOGRAPHIC-STRUCTURE; POPULATION-GENETICS; RECOMBINATION; PROGRAM; MULTIPLE; HISTORY; SIMCOAL; MODELS;

D O I：

10.1093/bioinformatics/btr124

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Genetic studies focus on increasingly larger genomic regions of both extant and ancient DNA, and there is a need for simulation software to match these technological advances. We present here a new coalescent-based simulation program fastsimcoal, which is able to quickly simulate a variety of genetic markers scattered over very long genomic regions with arbitrary recombination patterns under complex evolutionary scenarios.

引用

页码：1332 / 1334

页数：3

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