MSMS: a coalescent simulation program including recombination, demographic structure and selection at a single locus

被引：254

作者：

Ewing, Gregory ^{[1
,2
]}

Hermisson, Joachim ^{[1
,2
]}

机构：

[1] Univ Vienna, Dept Math, A-1090 Vienna, Austria

[2] Max F Perutz Labs, A-1030 Vienna, Austria

来源：

BIOINFORMATICS | 2010年 / 26卷 / 16期

关键词：

MOLECULAR POPULATION-GENETICS; SOFT SWEEPS; HITCHHIKING; ADAPTATION; MODEL;

D O I：

10.1093/bioinformatics/btq322

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have implemented a coalescent simulation program for a structured population with selection at a single diploid locus. The program includes the functionality of the simulator ms to model population structure and demography, but adds a model for deme- and time-dependent selection using forward simulations. The program can be used, e.g. to study hard and soft selective sweeps in structured populations or the genetic footprint of local adaptation. The implementation is designed to be easily extendable and widely deployable. The interface and output format are compatible with ms. Performance is comparable even with selection included.

引用

页码：2064 / 2065

页数：2

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