共 210 条
Neuroimmune endocrine effects of antidepressants
被引:31
作者:

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Rybka, Joanna
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机构:
Roehampton Univ, Dept Life Sci, Hlth Sci Res Ctr, Psychoimmunol Translat Lab, London SW15 4JD, England Roehampton Univ, Dept Life Sci, Hlth Sci Res Ctr, Psychoimmunol Translat Lab, London SW15 4JD, England

Carvalho, Livia A.
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Roehampton Univ, Dept Life Sci, Hlth Sci Res Ctr, Psychoimmunol Translat Lab, London SW15 4JD, England Roehampton Univ, Dept Life Sci, Hlth Sci Res Ctr, Psychoimmunol Translat Lab, London SW15 4JD, England
机构:
[1] Roehampton Univ, Dept Life Sci, Hlth Sci Res Ctr, Psychoimmunol Translat Lab, London SW15 4JD, England
关键词:
antidepressant agents;
biological markers;
human;
cytokines;
neuroinflammation;
psychoneuroimmunology;
endophenotype;
MAJOR DEPRESSIVE DISORDER;
PITUITARY-ADRENAL AXIS;
GLUCOCORTICOID-RECEPTOR FUNCTION;
RAT PINEAL-GLAND;
CORTICOTROPIN-RELEASING-FACTOR;
DEXAMETHASONE SUPPRESSION TEST;
CIRCADIAN-RHYTHM DISTURBANCES;
NOCTURNAL MELATONIN SECRETION;
SEASONAL AFFECTIVE-DISORDER;
INCREASE PLASMA SEROTONIN;
D O I:
10.2147/NDT.S16409
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Antidepressant pharmacotherapy is to date the most often used treatment for depression, but the exact mechanism of action underlying its therapeutic effect is still unclear. Many theories have been put forward to account for depression, as well as antidepressant activity, but none of them is exhaustive. Neuroimmune endocrine impairment is found in depressed patients; high levels of circulating corticosteroids along with hyperactivation of the immune system, high levels of proinflammatory cytokines, low levels of melatonin in plasma and urine, and disentrainment of circadian rhythms have been demonstrated. Moreover, antidepressant treatment seems to correct or at least to interfere with these alterations. In this review, we summarize the complex neuroimmune endocrine and chronobiological alterations found in patients with depression and how these systems interact with each other. We also explain how antidepressant therapy can modify these systems, along with some possible mechanisms of action shown in animal and human models.
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页码:65 / 83
页数:19
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共 210 条
[81]
Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide
[J].
Huang, Y.
;
Henry, C. J.
;
Dantzer, R.
;
Johnson, R. W.
;
Godbout, J. P.
.
NEUROBIOLOGY OF AGING,
2008, 29 (11)
:1744-1753

Huang, Y.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
Ohio State Univ, Inst Behav Med Res, Columbus, OH 43210 USA Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

Henry, C. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
Ohio State Univ, Inst Behav Med Res, Columbus, OH 43210 USA Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

Dantzer, R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

Johnson, R. W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

Godbout, J. P.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
Ohio State Univ, Inst Behav Med Res, Columbus, OH 43210 USA Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
[82]
A psychoneuroimmunological review on cytokines involved in antidepressant treatment response
[J].
Janssen, Debbie G. A.
;
Caniato, Riccardo N.
;
Verster, Joris C.
;
Baune, Bernhard T.
.
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,
2010, 25 (03)
:201-215

Janssen, Debbie G. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Utrecht, Utrecht Inst Pharmaceut Sci, Sect Psychopharmacol, Utrecht, Netherlands James Cook Univ, Sch Med & Dent, Dept Psychiat & Psychiat Neurosci, Townsville, Qld 4811, Australia

Caniato, Riccardo N.
论文数: 0 引用数: 0
h-index: 0
机构:
James Cook Univ, Sch Med & Dent, Dept Psychiat & Psychiat Neurosci, Townsville, Qld 4811, Australia James Cook Univ, Sch Med & Dent, Dept Psychiat & Psychiat Neurosci, Townsville, Qld 4811, Australia

Verster, Joris C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Utrecht, Utrecht Inst Pharmaceut Sci, Sect Psychopharmacol, Utrecht, Netherlands James Cook Univ, Sch Med & Dent, Dept Psychiat & Psychiat Neurosci, Townsville, Qld 4811, Australia

Baune, Bernhard T.
论文数: 0 引用数: 0
h-index: 0
机构:
James Cook Univ, Sch Med & Dent, Dept Psychiat & Psychiat Neurosci, Townsville, Qld 4811, Australia James Cook Univ, Sch Med & Dent, Dept Psychiat & Psychiat Neurosci, Townsville, Qld 4811, Australia
[83]
Light during darkness and cancer: Relationships in circadian photoreception and tumor biology
[J].
Jasser, SA
;
Blask, DE
;
Brainard, GC
.
CANCER CAUSES & CONTROL,
2006, 17 (04)
:515-523

Jasser, SA
论文数: 0 引用数: 0
h-index: 0
机构: Thomas Jefferson Univ, Dept Neurol, Light Res Program, Philadelphia, PA 19107 USA

Blask, DE
论文数: 0 引用数: 0
h-index: 0
机构: Thomas Jefferson Univ, Dept Neurol, Light Res Program, Philadelphia, PA 19107 USA

Brainard, GC
论文数: 0 引用数: 0
h-index: 0
机构: Thomas Jefferson Univ, Dept Neurol, Light Res Program, Philadelphia, PA 19107 USA
[84]
Association of IL-6, Hypothalamus-Pituitary-Adrenal Axis Function, and Depression in Patients With Cancer
[J].
Jehn, Christian Friedrich
;
Kuehnhardt, Dagmar
;
Bartholomae, Andrea
;
Pfeiffer, Sebastian
;
Schmid, Peter
;
Possinger, Kurt
;
Flath, Bernd Christian
;
Lueftner, Diana
.
INTEGRATIVE CANCER THERAPIES,
2010, 9 (03)
:270-275

Jehn, Christian Friedrich
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany

Kuehnhardt, Dagmar
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany

Bartholomae, Andrea
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany

Pfeiffer, Sebastian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany

Schmid, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany

Possinger, Kurt
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany

Flath, Bernd Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany

Lueftner, Diana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany Univ Hosp Charite, Dept Hematol & Oncol, D-10117 Berlin, Germany
[85]
Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-κB Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury
[J].
Jin, Wei
;
Wang, Handong
;
Yan, Wei
;
Xu, Lizhi
;
Wang, Xiaoliang
;
Zhao, Xiaoning
;
Yang, Xiaohe
;
Chen, Gang
;
Ji, Yan
.
MEDIATORS OF INFLAMMATION,
2008, 2008

Jin, Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China

Wang, Handong
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China

Yan, Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurosurg, Hangzhou 310009, Zhejiang, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China

Xu, Lizhi
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Med, Dept Med Genet, Nanjing 210093, Jiangsu Prov, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China

Wang, Xiaoliang
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China

Zhao, Xiaoning
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Med, Dept Med Genet, Nanjing 210093, Jiangsu Prov, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China

Yang, Xiaohe
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Med, Dept Med Genet, Nanjing 210093, Jiangsu Prov, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China

Chen, Gang
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China

Ji, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Sch Med, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Nanjing 210008, Jiangsu Prov, Peoples R China Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurosurg, Nanjing 210002, Jiangsu Prov, Peoples R China
[86]
Possible association between -G308A tumour necrosis factor-α gene polymorphism and major depressive disorder in the Korean population
[J].
Jun, TY
;
Pae, CU
;
Hoon-Han
;
Chae, JH
;
Bahk, WM
;
Kim, KS
;
Serretti, A
.
PSYCHIATRIC GENETICS,
2003, 13 (03)
:179-181

Jun, TY
论文数: 0 引用数: 0
h-index: 0
机构: Catholic Univ Korea, Coll Med, Dept Psychiat, Kangnam St Mary Hosp, Seoul 137701, South Korea

Pae, CU
论文数: 0 引用数: 0
h-index: 0
机构: Catholic Univ Korea, Coll Med, Dept Psychiat, Kangnam St Mary Hosp, Seoul 137701, South Korea

Hoon-Han
论文数: 0 引用数: 0
h-index: 0
机构: Catholic Univ Korea, Coll Med, Dept Psychiat, Kangnam St Mary Hosp, Seoul 137701, South Korea

Chae, JH
论文数: 0 引用数: 0
h-index: 0
机构: Catholic Univ Korea, Coll Med, Dept Psychiat, Kangnam St Mary Hosp, Seoul 137701, South Korea

Bahk, WM
论文数: 0 引用数: 0
h-index: 0
机构: Catholic Univ Korea, Coll Med, Dept Psychiat, Kangnam St Mary Hosp, Seoul 137701, South Korea

Kim, KS
论文数: 0 引用数: 0
h-index: 0
机构: Catholic Univ Korea, Coll Med, Dept Psychiat, Kangnam St Mary Hosp, Seoul 137701, South Korea

Serretti, A
论文数: 0 引用数: 0
h-index: 0
机构: Catholic Univ Korea, Coll Med, Dept Psychiat, Kangnam St Mary Hosp, Seoul 137701, South Korea
[87]
Prednisolone suppression test in depression: prospective study of the role of HPA axis dysfunction in treatment resistance
[J].
Juruena, Mario F.
;
Pariante, Carmine M.
;
Papadopoulos, Andrew S.
;
Poon, Lucia
;
Lightman, Stafford
;
Cleare, Anthony J.
.
BRITISH JOURNAL OF PSYCHIATRY,
2009, 194 (04)
:342-349

Juruena, Mario F.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Psychiat, Sect Neurobiol Mood Disorders & Stress, Psychiat & Immunol Lab, SPI Lab, London SE5 8AF, England
Bethlem Royal & Maudsley Hosp, Natl Affect Disorders Unit, Beckenham BR3 3BX, Kent, England Inst Psychiat, Sect Neurobiol Mood Disorders, London SE5 8AF, England

Pariante, Carmine M.
论文数: 0 引用数: 0
h-index: 0
机构: Inst Psychiat, Sect Neurobiol Mood Disorders, London SE5 8AF, England

Papadopoulos, Andrew S.
论文数: 0 引用数: 0
h-index: 0
机构:
Bethlem Royal & Maudsley Hosp, Natl Affect Disorders Unit, Beckenham BR3 3BX, Kent, England Inst Psychiat, Sect Neurobiol Mood Disorders, London SE5 8AF, England

Poon, Lucia
论文数: 0 引用数: 0
h-index: 0
机构:
Bethlem Royal & Maudsley Hosp, Natl Affect Disorders Unit, Beckenham BR3 3BX, Kent, England Inst Psychiat, Sect Neurobiol Mood Disorders, London SE5 8AF, England

Lightman, Stafford
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS8 1TH, Avon, England Inst Psychiat, Sect Neurobiol Mood Disorders, London SE5 8AF, England

Cleare, Anthony J.
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Psychiat, Sect Neurobiol Mood Disorders, London SE5 8AF, England
Bethlem Royal & Maudsley Hosp, Natl Affect Disorders Unit, Beckenham BR3 3BX, Kent, England Inst Psychiat, Sect Neurobiol Mood Disorders, London SE5 8AF, England
[88]
CRH and the immune system
[J].
Karalis, K
;
Louis, JM
;
Bae, D
;
Hilderbrand, H
;
Majzoub, JA
.
JOURNAL OF NEUROIMMUNOLOGY,
1997, 72 (02)
:131-136

Karalis, K
论文数: 0 引用数: 0
h-index: 0

Louis, JM
论文数: 0 引用数: 0
h-index: 0

Bae, D
论文数: 0 引用数: 0
h-index: 0

Hilderbrand, H
论文数: 0 引用数: 0
h-index: 0

Majzoub, JA
论文数: 0 引用数: 0
h-index: 0
[89]
Efficacy of the Novel Antidepressant Agomelatine on the Circadian Rest-Activity Cycle and Depressive and Anxiety Symptoms in Patients With Major Depressive Disorder: A Randomized, Double-Blind Comparison With Sertraline
[J].
Kasper, Siegfried
;
Hajak, Goeran
;
Wulff, Katharina
;
Hoogendijk, Witte J. G.
;
Luis Montejo, Angel
;
Smeraldi, Enrico
;
Rybakowski, Janusz K.
;
Quera-Salva, Maria-Antonia
;
Wirz-Justice, Anna M.
;
Picarel-Blanchot, Francoise
;
Bayle, Franck J.
.
JOURNAL OF CLINICAL PSYCHIATRY,
2010, 71 (02)
:109-120

论文数: 引用数:
h-index:
机构:

Hajak, Goeran
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Regensburg, Dept Psychiat Psychosomat & Psychotherapy, Regensburg, Germany Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Wulff, Katharina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, John Radcliffe Hosp, Nuffield Lab Ophthalmol, Oxford OX3 9DU, England Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Hoogendijk, Witte J. G.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Luis Montejo, Angel
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Univ Salamanca, Salamanca, Spain Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Smeraldi, Enrico
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Milan, Osped San Raffaele, Dept Clin Neurosci, I-20127 Milan, Italy Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Rybakowski, Janusz K.
论文数: 0 引用数: 0
h-index: 0
机构:
Poznan Univ Med Sci, Dept Adult Psychiat, Poznan, Poland Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Quera-Salva, Maria-Antonia
论文数: 0 引用数: 0
h-index: 0
机构:
Hop Raymond Poincare, Sleep Unit, Garches, France Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Wirz-Justice, Anna M.
论文数: 0 引用数: 0
h-index: 0
机构:
Psychiat Univ Clin, Ctr Chronobiol, Basel, Switzerland Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Picarel-Blanchot, Francoise
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Rech Int Servier, F-92415 Courbevoie, France Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria

Bayle, Franck J.
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Hosp St Anne, Paris, France Med Univ Vienna, Dept Psychiat & Psychotherapy, AKH, MUV, A-1090 Vienna, Austria
[90]
EFFECT OF CHRONIC ANTIDEPRESSANT TREATMENT WITH ADINAZOLAM AND DESIPRAMINE ON MELATONIN OUTPUT
[J].
KENNEDY, SH
;
BROWN, GM
.
PSYCHIATRY RESEARCH,
1992, 43 (02)
:177-185

KENNEDY, SH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV TORONTO, DEPT PSYCHIAT, TORONTO M5S 1A1, ONTARIO, CANADA

论文数: 引用数:
h-index:
机构: