On the preparative use of recombinant pig α(1-3)galactosyl-transferase

被引：16

作者：

Baisch, G ^{[1
]}

Öhrlein, R ^{[1
]}

Kolbinger, F ^{[1
]}

Streiff, M ^{[1
]}

机构：

[1] Novartis Pharma AG, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(98)00266-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of non-natural N-acyl derivatives of lactosamine is incubated with recombinant alpha(1-3)galactosyl-transferase and UDP-galactose. The enzyme shows a high promiscuity towards the nonnatural accepters. It selectively transfers a galactose unit onto the 3-OH group of the terminal beta-linked galactose in an alpha-mode to give an array of linear-B trisaccharides. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1575 / 1578

页数：4

共 15 条

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