Enzymatic fucosylations of non-natural acceptors with non-natural donor-sugars

被引：19

作者：

Baisch, G ^{[1
]}

Ohrlein, R ^{[1
]}

Katopodis, A ^{[1
]}

机构：

[1] NOVARTIS PHARMA AG,CH-4002 BASEL,SWITZERLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(97)00447-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Non-natural sialyl-lactosamine derivatives are treated with recombinant fucosyl-transferase VI in the presence of non-natural guanosine diphosphate-activated donor sugars. The biocatalyst transfers the non-natural donor sugars with the same regio- and stereospecificity as the parent fucose to the non-natural accepters yielding sialyl-le(x)-oligosaccharide libraries. (C) 1997 Elsevier Science Ltd.

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页码：2431 / 2434

页数：4

相关论文

共 20 条

[1] Enzymatic galactosylation of non-natural glucosamide-acceptors [J].

Baisch, G ;

Ohrlein, R ;

Ernst, B .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) :749-754

[2] Enzymatic alpha(2-3)-sialylation of non-natural disaccharides with cloned sialyl-transferase [J].

Baisch, G ;

Ohrlein, R ;

Streiff, M ;

Ernst, B .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) :755-758

[3] Enzymatic fucosylation of non-natural trisaccharides with cloned fucosyltransferase VI [J].

Baisch, G ;

Ohrlein, R ;

Katopodis, A ;

Ernst, B .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (07) :759-762

[4] Convenient chemoenzymatic synthesis of beta-purine-diphosphate sugars (GDP-fucose-analogues) [J].

Baisch, G ;

Ohrlein, R .

BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (02) :383-391

[5] CHEMICALLY SYNTHESIZED OLIGOSACCHARIDES, 1994 - A SEARCHABLE TABLE OF GLYCOSIDIC LINKAGES [J].

BARRESI, F ;

HINDSGAUL, O .

JOURNAL OF CARBOHYDRATE CHEMISTRY, 1995, 14 (08) :1043-1087

[6] CRACKING THE CARBOHYDRATE CODE FOR SELECTIN RECOGNITION [J].

BERTOZZI, CR .

CHEMISTRY & BIOLOGY, 1995, 2 (11) :703-708

[7] Carbohydrate recognition systems: Functional triads in cell-cell interactions [J].

Crocker, PR ;

Feizi, T .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1996, 6 (05) :679-691

[8]

EDWARDS M, 1991, CURR OPIN THER PAT, P1617

[9] CARBOHYDRATE-DEPENDENT CELL-ADHESION [J].

FUKUDA, M .

BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (03) :207-215

[10] THE SIALYL LEWIS(X) GROUP AND ITS ANALOGS AS LIGANDS FOR SELECTINS - CHEMOENZYMATIC SYNTHESES AND BIOLOGICAL FUNCTIONS [J].

GIANNIS, A .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1994, 33 (02) :178-180