Transforming growth factor-β signaling in stem cells and cancer

被引：159

作者：

Mishra, L

Derynck, R

Mishra, B

机构：

[1] Georgetown Univ, Dept Surg, Med Lombardi Canc Ctr, Lab CNS Dev, Washington, DC 20007 USA

[2] Dept Vet Affairs, Washington, DC 20049 USA

[3] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Cell Biol Program, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Program Dev Biol, San Francisco, CA 94143 USA

来源：

SCIENCE | 2005年 / 310卷 / 5745期

关键词：

D O I：

10.1126/science.1118389

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transforming growth factor-beta(TGF-beta) and TGF-beta-related proteins, such as the bone morphogenetic proteins, have emerged as key regulators of stem cell renewal and differentiation. These proteins have disparate roles in regulating the biology of embryonic stem cells and tumor suppression, and they help define the selection of cell fate and the progression of differentiation along a lineage. Here we illustrate their roles in embryonic stem cells and in the differentiation of neural, hematopoietic, mesenchymal, and gastrointestinal epithelial stem cells.

引用

页码：68 / 71

页数：4

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