The links between axin and carcinogenesis

被引：207

作者：

Salahshor, S ^{[1
]}

Woodgett, JR ^{[1
]}

机构：

[1] Ontario Canc Inst, Div Expt Therapeut, Toronto, ON M5G 2M9, Canada

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2005年 / 58卷 / 03期

关键词：

D O I：

10.1136/jcp.2003.009506

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The products of the two mammalian Axin genes (Axin1 and its homologue Axin2) are essential for the degradation of beta catenin, a component of Wnt signalling that is frequently dysregulated in cancer cells. Axin is a multidomain scaffold protein that has many functions in biological signalling pathways. Overexpression of axin results in axis duplication in mouse embryos. Wnt signalling activity determines dorsal - ventral axis formation in vertebrates, implicating axin as a negative regulator of this signalling pathway. In addition, Wnts modulate pattern formation and the morphogenesis of most organs by influencing and controlling cell proliferation, motility, and fate. Defects in different components of the Wnt signalling pathway promote tumorigenesis and tumour progression. Recent biochemical studies of axins indicate that these molecules are the primary limiting components of this pathway. This review explores the intriguing connections between defects in axin function and human diseases.

引用

页码：225 / 236

页数：12

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