Tumour-stromal interactions -: Transforming growth factor-β isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis

被引:57
作者
Pollard, JW
机构
[1] Albert Einstein Coll Med, Dept Dev & Mol Biol, Ctr Study Reprod Biol & Womens Hlth, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Dept OB Gyn & Womens Hlth, Ctr Study Reprod Biol & Womens Hlth, Bronx, NY 10461 USA
关键词
apoptosis; ductal morphogenesis; growth factor; mammary gland; SMAD;
D O I
10.1186/bcr301
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The mammary gland undergoes morphogenesis through the entire reproductive life of mammals. In mice, ductal outgrowth from the nipple across the fat pad results in an intricate, well spaced ductal tree that further ramifies and develops alveolar structures during pregnancy. Ductal morphogenesis is regulated by the concerted action of circulating steroid and polypeptide hormones, and local epithelial-mesenchymal inductive signals. Transforming growth factor (TGF)-beta (1-3) and hepatocyte growth factor (HGF)/scatter factor (SF) are important components of this latter signaling pathway. TGF-beta (1) and TGF-beta (3) have roles in both promotion and inhibition of branching morphogenesis that are dependent on concentration and context. HGF/SF promotes ductal outgrowth and tubule formation in the mammary gland. These data suggest that these two growth factors have complementary roles in promoting mammary ductal morphogenesis and in maintaining ductal spacing. In addition, TGF-beta (3) triggers apoptosis in the alveolar epithelia, which is a necessary component of mammary gland involution and return of the ductal structure to a virgin-like state after lactation.
引用
收藏
页码:230 / 237
页数:8
相关论文
共 43 条
[31]   INHIBITION OF MAMMARY DUCT DEVELOPMENT BUT NOT ALVEOLAR OUTGROWTH DURING PREGNANCY IN TRANSGENIC MICE EXPRESSING ACTIVE TGF-BETA-1 [J].
PIERCE, DF ;
JOHNSON, MD ;
MATSUI, Y ;
ROBINSON, SD ;
GOLD, LI ;
PURCHIO, AF ;
DANIEL, CW ;
HOGAN, BLM ;
MOSES, HL .
GENES & DEVELOPMENT, 1993, 7 (12A) :2308-2317
[32]   Expression of transforming growth factors alpha and beta-1 messenger RNA in the bovine mammary gland during different stages of development and lactation [J].
Plath, A ;
Einspanier, R ;
Peters, F ;
Sinowatz, F ;
Schams, D .
JOURNAL OF ENDOCRINOLOGY, 1997, 155 (03) :501-511
[33]  
Ponzetto C, 2000, INT J DEV BIOL, V44, P645
[34]  
ROBINSON SD, 1991, DEVELOPMENT, V113, P867
[35]   TGF-BETA SUPPRESSES CASEIN SYNTHESIS IN MOUSE MAMMARY EXPLANTS AND MAY PLAY A ROLE IN CONTROLLING MILK LEVELS DURING PREGNANCY [J].
ROBINSON, SD ;
ROBERTS, AB ;
DANIEL, CW .
JOURNAL OF CELL BIOLOGY, 1993, 120 (01) :245-251
[36]   Essential role of Gab1 for signaling by the c-Met receptor in vivo [J].
Sachs, M ;
Brohmann, H ;
Zechner, D ;
Müller, T ;
Hülsken, J ;
Walther, I ;
Schaeper, U ;
Birchmeier, C ;
Birchmeier, W .
JOURNAL OF CELL BIOLOGY, 2000, 150 (06) :1375-1384
[37]   Stimulation of DNA synthesis and cell proliferation of human mammary myoepithelial-like cells by hepatocyte growth factor/scatter factor depends on heparan sulfate proteoglycans and sustained phosphorylation of mitogen-activated protein kinases p42/44 [J].
Sergeant, N ;
Lyon, M ;
Rudland, PS ;
Fernig, DG ;
Delehedde, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (22) :17094-17099
[38]   REVERSIBLE INHIBITION OF MAMMARY-GLAND GROWTH BY TRANSFORMING GROWTH-FACTOR-BETA [J].
SILBERSTEIN, GB ;
DANIEL, CW .
SCIENCE, 1987, 237 (4812) :291-293
[39]   Roles of hepatocyte growth factor scatter factor and transforming growth factor-β1 in mammary gland ductal morphogenesis [J].
Soriano, JV ;
Pepper, MS ;
Orci, L ;
Montesano, R .
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1998, 3 (02) :133-150
[40]   Transforming growth factor-β and breast cancer -: Lessons learned from genetically altered mouse models [J].
Wakefield, LM ;
Yang, YA ;
Dukhanina, O .
BREAST CANCER RESEARCH, 2000, 2 (02) :100-106