Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis

被引：34

作者：

Bai, Suwen ^{[1
,2
]}

Wang, Zunyun ^{[2
]}

Wang, Minghua ^{[1
]}

Li, Junai ^{[1
]}

Wei, Yuan ^{[1
]}

Xu, Ruihuan ^{[1
]}

Du, Juan ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Affiliated Hosp 2, Longgang Dist Peoples Hosp, Shenzhen, Peoples R China

[2] Anhui Med Univ, Sch Basic Med Sci, Hefei, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

tumor-derived exosomes; metastasis; pre-metastatic niche; angiogenesis; immunosuppression; LYMPH-NODE METASTASIS; EPITHELIAL-MESENCHYMAL TRANSITION; GASTROINTESTINAL STROMAL TUMOR; CERVICAL-CANCER PATIENTS; ACUTE MYELOID-LEUKEMIA; BRAIN METASTASIS; BREAST-CANCER; BONE METASTASIS; OVARIAN-CANCER; HEPATOCELLULAR-CARCINOMA;

D O I：

10.3389/fcell.2022.752818

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Tumor-derived exosomes (TDEs) are actively produced and released by tumor cells and carry messages from tumor cells to healthy cells or abnormal cells, and they participate in tumor metastasis. In this review, we explore the underlying mechanism of action of TDEs in tumor metastasis. TDEs transport tumor-derived proteins and non-coding RNA to tumor cells and promote migration. Transport to normal cells, such as vascular endothelial cells and immune cells, promotes angiogenesis, inhibits immune cell activation, and improves chances of tumor implantation. Thus, TDEs contribute to tumor metastasis. We summarize the function of TDEs and their components in tumor metastasis and illuminate shortcomings for advancing research on TDEs in tumor metastasis.

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页数：22

相关论文

共 422 条

[11]

O-GlcNAcylation of NF-κB Promotes Lung Metastasis of Cervical Cancer Cells via Upregulation of CXCR4 Expression [J].

Ali, Akhtar ;

Kim, Sung Hwan ;

Kim, Min Jun ;

Choi, Mee Young ;

Kang, Sang Soo ;

Cho, Gyeong Jae ;

Kim, Yoon Sook ;

Choi, Jun-Young ;

Choi, Wan Sung .

MOLECULES AND CELLS, 2017, 40 (07) :476-484

[12]

Genetic mutations associated with lung cancer metastasis to the brain [J].

Aljohani, Hashim M. ;

Aittaleb, Mohamed ;

Furgason, John M. ;

Amaya, Peter ;

Deeb, Ayham ;

Chalmers, Jeffery J. ;

Bahassi, El Mustapha .

MUTAGENESIS, 2018, 33 (02) :137-145

[13]

Pulmonary metastasis of head and neck cancer: surgical removal outcomes from a tertiary care center [J].

AlShammari, Abdullah ;

Almasri, Talal ;

Sarraj, Jumana ;

AlAshgar, Omniyah ;

Ahmed, Mohamed Hussein ;

AlKattan, Khaled ;

Saleh, Waleed .

INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2020, 36 (03) :199-206

[14]

ASOH Y, 1990, Neurologia Medico-Chirurgica, V30, P884, DOI 10.2176/nmc.30.884

[15]

Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion [J].

Atay, Safinur ;

Banskota, Samagya ;

Crow, Jennifer ;

Sethi, Geetika ;

Rink, Lori ;

Godwin, Andrew K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (02) :711-716

[16]

RETRACTED: miR-135b Delivered by Gastric Tumor Exosomes Inhibits FOXO1 Expression in Endothelial Cells and Promotes Angiogenesis (Retracted article. See vol. 30, pg. 2636, 2022) [J].

Bai, Ming ;

Li, Jialu ;

Yang, Haiou ;

Zhang, Haiyang ;

Zhou, Zhengyang ;

Deng, Ting ;

Zhu, Kegan ;

Ning, Tao ;

Fan, Qian ;

Ying, Guoguang ;

Ba, Yi .

MOLECULAR THERAPY, 2019, 27 (10) :1772-1783

[17]

EMT, MET, Plasticity, and Tumor Metastasis [J].

Bakir, Basil ;

Chiarella, Anna M. ;

Pitarresi, Jason R. ;

Rustgi, Anil K. .

TRENDS IN CELL BIOLOGY, 2020, 30 (10) :764-776

[18]

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences [J].

Balaj, Leonora ;

Lessard, Ryan ;

Dai, Lixin ;

Cho, Yoon-Jae ;

Pomeroy, Scott L. ;

Breakefield, Xandra O. ;

Skog, Johan .

NATURE COMMUNICATIONS, 2011, 2

[19]

Local Treatment of Breast Cancer Liver Metastasis [J].

Bale, Reto ;

Putzer, Daniel ;

Schullian, Peter .

CANCERS, 2019, 11 (09)

[20]

Metastasis-associated miR-23a from nasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing a novel target gene TSGA10 [J].

Bao, Lili ;

You, Bo ;

Shi, Si ;

Shan, Ying ;

Zhang, Qicheng ;

Yue, Huijun ;

Zhang, Jie ;

Zhang, Wei ;

Shi, Yunwei ;

Liu, Yifei ;

Wang, Xin ;

Liu, Dong ;

You, Yiwen .

ONCOGENE, 2018, 37 (21) :2873-2889

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