Messages from ultrahigh resolution crystal structures

被引：55

作者：

Longhi, S ^{[1
]}

Czjzek, M ^{[1
]}

Cambillau, C ^{[1
]}

机构：

[1] IBSM, Lab Architecture & Fonction Macromol Biol AFMB, CNRS, UPR 9039, F-13402 Marseille 20, France

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(98)80093-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ever growing availability of macromolecular crystal structures determined at atomic resolution has now reached a critical size, making it possible to obtain statistically unbiased data on both protein stereochemistry and the validity of the parameters used in their refinement. Besides the determination of the precise geometry of proteins and their active sites, high resolution structures have made it possible to check the application of normal mode calculations, to calculate charge density distributions and to analyze hydration shells around protein molecules. Even if only a few structures involve protein complexes, either with ligands or prosthetic groups, the information obtained in these cases is of great interest for obtaining the physical parameters of these interactions.

引用

页码：730 / 737

页数：8

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