In vitro evaluation of the effects of electrospun PCL nanofiber mats containing the microalgae Spirulina (Arthrospira) extract on primary astrocytes

被引：42

作者：

Kim, Sung Hoon ^{[1
]}

Shin, Chungwhan ^{[1
]}

Min, Seul Ki ^{[1
]}

Jung, Sang-Myung ^{[1
]}

Shin, Hwa Sung ^{[1
]}

机构：

[1] Inha Univ, Dept Biol Engn, Inchon 402751, South Korea

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2012年 / 90卷

关键词：

Spirulina; Electrospun nanofiber; Astrocyte; CNS; Tissue engineering; Polycaprolactone; SPINAL-CORD; REGENERATION; ACTIVATION; REPAIR;

D O I：

10.1016/j.colsurfb.2011.10.004

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The blue-green microalgae, Spirulina, a harmless food and pharmaceutical additive, has several bioactive compounds that have therapeutic functions. Polycaprolactone (PCL) is a biocompatible and biodegradable polymer that has widely been used for tissue engineering. The electrospun PCL nanofiber containing Spirulina (PCL-Spirulina) was fabricated and tested as a potential extracellular matrix material for a culture of primary astrocytes, which play important roles in CNS injured systems. Spirulina extract was observed to increase growth and metabolic activity of rat primary astrocytes without any harm once added to the culture media. However. PCL-Spirulina nanofiber was proven to alleviate astrocyte activity. Through this research and to the best of our knowledge, we first suggest a novel composite nanomaterial, an electrospun PCL-Spirulina nanofiber that could be used to treat CNS injured systems. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：113 / 118

页数：6

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