A DNA duplex-based, tailor-made, fluorescent sensor for porphyrin derivatives

被引：25

作者：

Fujimoto, Kazuhisa ^{[1
]}

Muto, Yu ^{[1
]}

Inouye, Masahiko ^{[1
]}

机构：

[1] Toyama Univ, Grad Sch Pharmaceut Sci, Toyama 9300194, Japan

来源：

BIOCONJUGATE CHEMISTRY | 2008年 / 19卷 / 06期

关键词：

D O I：

10.1021/bc800133e

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We synthesized a DNA-based fluorescent sensor, tailored to the recognition and signaling for hydrophobic guest molecules. The sensor molecule is made of three functional moieties, per-O-methylated P-cyclodextrin (per-Me-beta-CD), DNA, and pyrene as guest-binding, dimerizing, and signaling ones, respectively. Addition of a porphyrin derivative as a hydrophobic guest molecule induced emission switching of the sensor molecule from monomer to excimer due to the DNA hybridization promoted by the host-guest binding.

引用

页码：1132 / 1134

页数：3

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