Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents

被引：311

作者：

Bhat, BA

Dhar, KL ^{[1
]}

Puri, SC

Saxena, AK

Shanmugavel, M

Qazi, GN

机构：

[1] Reg Res Lab, CSIR, Div Nat Prod Chem, Jammu 180001, India

[2] Reg Res Lab, CSIR, Div Pharmacol, Jammu 180001, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 12期

关键词：

chalcone analogues; in vitro cytotoxicity; cell lines;

D O I：

10.1016/j.bmcl.2005.03.121

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：3177 / 3180

页数：4

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