5-exo atom transfer cyclisation onto alkynes mediated by copper(I) complexes

被引：36

作者：

Clark, AJ ^{[1
]}

Battle, GM

Bridge, A

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Aventis Pharma Ltd, Dagenham RM10 7XS, Essex, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 10期

关键词：

radicals and radical reactions; cyclisations; copper and compounds; alkynes;

D O I：

10.1016/S0040-4039(01)00060-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multidentate amine derived copper(I) halide complexes mediate the atom transfer radical cyclisation of 1-halo-N-propargylacetamides. While cyclisation of trichloro- and dichloroacetamide derivatives leads to alpha,beta -unsaturated gamma -lactams containing the gem-dihalide functional group, monohaloacetamides give rise to either cyclised atom transfer or reduction products depending upon the solvent and catalyst used. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1999 / 2001

页数：3

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