Enantioselective alkynylation of aromatic ketones catalyzed by chiral camphorsulfonamide ligands

被引：143

作者：

Lu, G

Li, XS

Jia, X

Chan, WL

Chan, ASC ^{[1
]}

机构：

[1] Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 41期

关键词：

alkynylation; asymmetric catalysis; enantioselectivity; ketones; nucleophilic addition;

D O I：

10.1002/anie.200352013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The smooth addition of phenylacetylene to aromatic ketones in the presence of catalytic amounts of Cu(OTf)2 and camphorsulfonamide provides the corresponding tertiary propargylic alcohols in high yields and with up to 97% ee. This reaction represents a highly enantioselective catalytic addition of dialkynyl zinc reagents to simple ketones.

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收藏

页码：5057 / 5058

页数：2

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