学术探索
学术期刊
新闻热点
数据分析
智能评审

Quantitative trait loci in Drosophila

被引：298
作者：
Mackay, TFC [1 ]
机构：
[1] N Carolina State Univ, Dept Genet, Raleigh, NC 27695 USA
来源：
NATURE REVIEWS GENETICS | 2001年 / 2卷 / 01期
关键词：
D O I：
10.1038/35047544
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been accomplished for some quantitative trait loci in Drosophila. Drosophila quantitative trait loci have sex-, environment-and genotype-specific effects, and are often associated with molecular polymorphisms in non-coding regions of candidate genes. These observations offer valuable lessons to those seeking to understand quantitative traits in other organisms, including humans.
引用
收藏
页码：11 / 20
页数：10
相关论文
共 81 条
  • [61] Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster
    Nuzhdin, SV
    Pasyukova, EG
    Dilda, CL
    Zeng, ZB
    Mackay, TFC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (18) : 9734 - 9739
  • [62] Pasyukova EG, 2000, GENETICS, V156, P1129
  • [63] The future of genetic studies of complex human diseases
    Risch, N
    Merikangas, K
    [J]. SCIENCE, 1996, 273 (5281) : 1516 - 1517
  • [64] Robertson A., 1967, Heritage from Mendel., P265
  • [65] Gene targeting by homologous recombination in Drosophila
    Rong, YS
    Golic, KG
    [J]. SCIENCE, 2000, 288 (5473) : 2013 - 2018
  • [66] Comparative genomics of the eukaryotes
    Rubin, GM
    Yandell, MD
    Wortman, JR
    Miklos, GLG
    Nelson, CR
    Hariharan, IK
    Fortini, ME
    Li, PW
    Apweiler, R
    Fleischmann, W
    Cherry, JM
    Henikoff, S
    Skupski, MP
    Misra, S
    Ashburner, M
    Birney, E
    Boguski, MS
    Brody, T
    Brokstein, P
    Celniker, SE
    Chervitz, SA
    Coates, D
    Cravchik, A
    Gabrielian, A
    Galle, RF
    Gelbart, WM
    George, RA
    Goldstein, LSB
    Gong, FC
    Guan, P
    Harris, NL
    Hay, BA
    Hoskins, RA
    Li, JY
    Li, ZY
    Hynes, RO
    Jones, SJM
    Kuehl, PM
    Lemaitre, B
    Littleton, JT
    Morrison, DK
    Mungall, C
    O'Farrell, PH
    Pickeral, OK
    Shue, C
    Vosshall, LB
    Zhang, J
    Zhao, Q
    Zheng, XQH
    Zhong, F
    [J]. SCIENCE, 2000, 287 (5461) : 2204 - 2215
  • [67] Sax K, 1923, GENETICS, V8, P552
  • [68] SHRIMPTON AE, 1988, GENETICS, V118, P445
  • [69] SING CF, 1990, ANNU REV GENET, V24, P171
  • [70] REGULAR RESPONSES TO SELECTION .3. INTERACTION BETWEEN LOCATED POLYGENES
    SPICKETT, SG
    THODAY, JM
    [J]. GENETICAL RESEARCH, 1966, 7 (01) : 96 - &
123456789