MicroRNAs in Parkinson's disease

被引：113

作者：

Harraz, Maged M. ^{[1
,2
,3
]}

Dawson, Ted M. ^{[1
,2
,3
,4
]}

Dawson, Valina L. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Johns Hopkins Univ, Neuroregenerat Program, Inst Cell Engn, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Stem Cell Program, Inst Cell Engn, Sch Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Solomon H Snyder Dept Neurosci, Sch Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Dept Physiol, Sch Med, Baltimore, MD 21205 USA

来源：

JOURNAL OF CHEMICAL NEUROANATOMY | 2011年 / 42卷 / 02期

关键词：

MicroRNA; Small noncoding RNA; RNA induced silencing; Parkinson's disease; Neurodegenerative diseases; ALPHA-SYNUCLEIN EXPRESSION; POSTTRANSCRIPTIONAL REGULATION; FGF20; DIFFERENTIATION; ASSOCIATION; NEURONS; MIDBRAIN; GENES; 4E-BP; RISK;

D O I：

10.1016/j.jchemneu.2011.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs are small non-protein coding RNAs that regulate gene expression through post-transcriptional repression. Recent studies demonstrated the importance of microRNAs in the nervous system development, function and disease. Parkinson's disease is the second most prevalent neurodegenerative disease with only symptomatic treatment available. Recent success in using small RNAs as therapeutic targets hold a substantial promise for the Parkinson's disease field. Here we review recent work linking the microRNA pathway to Parkinson's disease. (C) 2011 Elsevier B.V. All rights reserved.

引用

收藏

页码：127 / 130

页数：4

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