Members of the miRNA-200 family regulate olfactory Neurogenesis

被引：233

作者：

Choi, Philip S. ^{[1
]}

Zakhary, Lisa ^{[1
]}

Choi, Wen-Yee

Caron, Sophie

Alvarez-Saavedra, Ezequiel ^{[2
]}

Miska, Eric A. ^{[2
]}

McManus, Mike ^{[3
]}

Harfe, Brian ^{[4
]}

Giraldez, Antonio J. ^{[6
]}

Horvitz, Robert H. ^{[2
]}

Schier, Alexander F. ^{[5
]}

Dulac, Catherine ^{[1
]}

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[4] Univ Florida, Dept Mol Genet & Microbiol, Gainesville, FL 32611 USA

[5] Broad Inst, Harvard Stem Cell Inst, Ctr Brain Sci, Div Sleep Med, Cambridge, MA 02139 USA

[6] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA

来源：

NEURON | 2008年 / 57卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.neuron.2007.11.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire of miRNAs expressed in olfactory tissues contains over 100 distinct miRNAs. A subset, including the miR-200 family, shows high olfactory enrichment and expression patterns consistent with a role during olfactory neurogenesis. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Our data support the notion that vertebrate tissue differentiation is controlled by conserved subsets of organ-specific miRNAs in both mouse and zebrafish and provide insights into control mechanisms underlying olfactory differentiation in vertebrates.

引用

页码：41 / 55

页数：15

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