Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival

被引:147
作者
Ragnarsson, G
Eiriksdottir, G
Johannsdottir, JT
Jonasson, JG
Egilsson, V
Ingvarsson, S
机构
[1] Univ Iceland, Dept Pathol, IS-121 Reykjavik, Iceland
[2] Natl Hosp Iceland, IS-121 Reykjavik, Iceland
关键词
cancer; chromosome; 1p; loss of heterozygosity; survival statistics; tumour-suppressor gene;
D O I
10.1038/sj.bjc.6690234
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The distal half of chromosome 1p was analysed with 15 polymorphic microsatellite markers in 683 human solid tumours at different locations. Loss of heterozygosity (LOH) was observed at least at one site in 369 cases or 54% of the tumours. LOHs detected ranged from 30-64%, depending on tumour location. The major results regarding LOH at different tumour locations were as follows: stomach, 20/38 (53%); colon and rectum, 60/109 (55%); lung, 38/63 (60%); breast, 145/238 (61%); endometrium, 18/25 (72%); ovary, 17/31 (55%); testis, 11/30 (37%); kidney, 22/73 (30%); thyroid, 4/14 (29%); and sarcomas, 9/14 (64%). High percentages of LOH were seen in the 1p36.3, 1p36.1, 1p35-p34.3, 1p32 and 1p31 regions. suggesting the presence of tumour-suppressor genes. All these regions on chromosome 1p show high LOH in more than one tumour type. However, distinct patterns of LOH were detected at different tumour locations. There was a significant separation of survival curves, with and without LOH at chromosome 1p, in the breast cancer patients. Multivariate analysis showed that LOH at 1p in breast tumours is a better indicator for prognosis than the other variables tested in our model, including nodal metastasis.
引用
收藏
页码:1468 / 1474
页数:7
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