Induction of host gene expression following infection of chicken embryo fibroblasts with oncogenic Marek's disease virus

被引:110
作者
Morgan, RW [1 ]
Sofer, L [1 ]
Anderson, AS [1 ]
Bernberg, EL [1 ]
Cui, J [1 ]
Burnside, J [1 ]
机构
[1] Univ Delaware, Dept Anim & Food Sci, Coll agr & Nat Resources, Agr Expt Stn, Newark, DE 19717 USA
关键词
D O I
10.1128/JVI.75.1.533-539.2001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Microarrays containing 1,126 nonredundant cDNAs selected from a chicken activated T-cell expressed sequence tag database (http://chickest.udel.edu) were used to examine changes in host cell gene expression that accompany infection of chicken embryo fibroblasts (CEF) with Marek's disease virus (MDV). Host genes that were reproducibly induced by infection of CEF with the oncogenic RB1B strain of MDV included macrophage inflammatory protein, interferon response factor 1, interferon-inducible protein, quiescence-specific protein, thymic shared antigen 1, major histocompatibility complex (MHC) class I, MHC class II, beta (2)-microglobulin, clusterin, interleukin-13 receptor alpha chain, ovotransferrin, a serine/threonine kinase, and avian leukosis virus subgroup J glycoprotein.
引用
收藏
页码:533 / 539
页数:7
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