Tick immunobiology

被引：180

作者：

Brossard, M

Wikel, SK

机构：

[1] Univ Connecticut, Ctr Hlth, Sch Med, Ctr Microbial Pathogenesis, Farmington, CT 06030 USA

[2] Univ Neuchatel, Inst Zool, CH-2007 Neuchatel, Switzerland

来源：

PARASITOLOGY | 2004年 / 129卷

关键词：

ticks; immunobiology; immunomodulation; saliva; genomics; proteomics;

D O I：

10.1017/S0031182004004834

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Ticks are of vast medical and veterinary public health importance due to direct damage Caused by feeding and their roles in transmitting well known and emerging infectious agents. Ticks and tick-borne pathogens stimulate the immune system of the host. Those immune interactions are of importance in tick biology, pathogen transmission and control of ticks and tick-borne diseases. Both innate and specific acquired immune defenses are involved in the responses of vertebrate hosts to infestation. Ticks have evolved countermeasures to Circumvent host immune defenses. This review addresses the immunobiology of the tick-host interface from the perspectives of the pharmacology of tick saliva; relationship of tick saliva to pathogen transmission; host immune responses to infestation; tick modulation of host immune defences; and genomic/ proteomic strategies for studying tick salivary gland molecules.

引用

页码：S161 / S176

页数：16

共 169 条

[71] Ixodes ricinus tick salivary gland extract inhibits IL-10 secretion and CD69 expression by mitogen-stimulated murine splenocytes and induces hyporesponsiveness in B lymphocytes [J].