Enantioselective addition of dialkylzinc to aldehydes catalyzed by (S)-2-(N,N-disubstituted aminomethyl)indoline

被引：55

作者：

Asami, M ^{[1
]}

Watanabe, H ^{[1
]}

Honda, K ^{[1
]}

Inoue, S ^{[1
]}

机构：

[1] Yokohama Natl Univ, Fac Engn, Dept Synthet Chem, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 23期

关键词：

D O I：

10.1016/S0957-4166(98)00446-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral di- or triamines, (S)-2-(N,N-disubstituted aminomethyl)indoline 1a-d, derived from (S)-indoline-2-carboxylic acid were efficient chiral catalysts for the enantioselective addition of dialkylzincs to aldehydes. The best results were obtained by employing 15 mol% of (S)-2-(4-methylpiperazin-1-ylmethyl)indoline Ic, and chiral secondary alcohols were obtained in up to 97% ee. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4165 / 4173

页数：9

共 25 条

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