Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)-3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent

被引：37

作者：

Chan, WN ^{[1
]}

Evans, JM ^{[1
]}

Hadley, MS ^{[1
]}

Herdon, HJ ^{[1
]}

Jerman, JC ^{[1
]}

Parsons, AA ^{[1
]}

Read, SJ ^{[1
]}

Stean, TO ^{[1
]}

Thompson, M ^{[1
]}

Upton, N ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期

关键词：

chromans; migraine; polycyclic heterocyclic compounds; SB-204269; receptor;

D O I：

10.1016/S0960-894X(98)00728-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Optimisation of novel cis- and trans-4-(substituted-amido)benzopyran-3-ol derivatives has led to the identification of SE-220453 20 with an in vivo pre-clinical CNS profile predictive of potential antimigraine activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：285 / 290

页数：6

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