Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

被引：61

作者：

Jia, Gaoxiang ^{[1
]}

Su, Ling ^{[1
]}

Singhal, Sunil ^{[2
]}

Liu, Xiangguo ^{[1
]}

机构：

[1] Shandong Univ, Sch Life Sci, Shandong Prov Key Lab Anim Cells & Dev Biol, Jinan 250100, Peoples R China

[2] Univ Penn, Dept Surg, Div Thorac Surg, Philadelphia, PA 19104 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2012年 / 364卷 / 1-2期

关键词：

SIRT6; Telomere structure; DNA repair; Metabolism; Mammalian aging; NF-KAPPA-B; BASE EXCISION-REPAIR; CALORIE RESTRICTION; CELL-SURVIVAL; AUTOPHAGY; STRESS; SIRTUINS; PROTEIN; DAMAGE; DEACETYLASE;

D O I：

10.1007/s11010-012-1236-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the characterization of Sir2 gene in yeast aging, its mammalian homologs Sirtuins 1-7 have been attracting attention from scientists with various research backgrounds. Among Sirtuins, SIRT1 is the most extensively studied. Recent progress on mammalian Sirtuins has shown that SIRT6 as a histone deacetylase may also play a critical role in regulating mammalian aging. This review summarizes recent advances on SIRT6 as a key modulator of telomere structure, DNA repair, metabolism, and NF-kappa B pathway in aging. In addition, we discuss the challenges that remain to be studied in SIRT6 biology.

引用

页码：345 / 350

页数：6

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