From chemical structure to environmental biosynthetic pathways: navigating marine invertebrate-bacteria associations

被引：29

作者：

Schmidt, EW ^{[1
]}

机构：

[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2005年 / 23卷 / 09期

关键词：

D O I：

10.1016/j.tibtech.2005.07.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Many natural products from marine invertebrates are promising drugs or drug leads but the problem of supply has delayed the development of these agents. Bacteria living in complex associations with animals are often proposed to be the real producers of 'invertebrate' metabolites. Recent advances in biosynthetic pathway discovery from these symbiotic bacteria herald a new era in which biosynthetic genes will be cloned rapidly to provide promising molecules from marine invertebrates.

引用

页码：437 / 440

页数：4

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