The function of APC/CCdh1 in cell cycle and beyond

被引：88

作者：

Li, Min ^{[1
]}

Zhang, Pumin ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

CELL DIVISION | 2009年 / 4卷

关键词：

ANAPHASE-PROMOTING COMPLEX; ETS-2 TRANSCRIPTION FACTORS; CHECKPOINT PROTEIN MAD2; S-PHASE; COMPLEX/CYCLOSOME APC/C; DEPENDENT DEGRADATION; CHROMATID SEPARATION; CHROMOSOME ALIGNMENT; DNA-REPLICATION; GENE-EXPRESSION;

D O I：

10.1186/1747-1028-4-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. Both APC(Cdc20) and APC(Cdh1) are implicated in the control of mitosis through mediating ubiquitination and degradation of important mitotic regulators such as cyclin B1, securin, and Plk1. In addition, APC(Cdh1) is thought to prevent premature S phase entry by limiting the accumulation of mitotic cyclins in G1 and to regulate processes unrelated to cell cycle. In this review, we will summarize our current understanding of APC(Cdh1) function in cell cycle and beyond.

引用

页数：7

共 91 条

[1] Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
Alani, RM
Young, AZ
Shifflett, CB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (14) : 7812 - 7816
[2] TRANSFORMING P21(RAS) MUTANTS AND C-ETS-2 ACTIVATE THE CYCLIN D1 PROMOTER THROUGH DISTINGUISHABLE REGIONS
ALBANESE, C
JOHNSON, J
WATANABE, G
EKLUND, N
VU, D
ARNOLD, A
PESTELL, RG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (40) : 23589 - 23597
[3] Xkid, a chromokinesin required for chromosome alignment on the metaphase plate
Antonio, C
Ferby, I
Wilhelm, H
Jones, M
Karsenti, E
Nebreda, AR
Vernos, I
[J]. CELL, 2000, 102 (04) : 425 - 435
[4] Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase
Bashir, T
Dorrello, NV
Amador, V
Guardavaccaro, D
Pagano, M
[J]. NATURE, 2004, 428 (6979) : 190 - 193
[5] The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
Bassermann, Florian
Frescas, David
Guardavaccaro, Daniele
Busino, Luca
Peschiaroli, Angelo
Pagano, Michele
[J]. CELL, 2008, 134 (02) : 256 - 267
[6] Involvement of the SCF complex in the control of Cdh1 degradation in S-phase
Benmaamar, R
Pagano, M
[J]. CELL CYCLE, 2005, 4 (09) : 1230 - 1232
[7] Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells
Carbone, GM
Napoli, S
Valentini, A
Cavalli, F
Watson, DK
Catapano, CV
[J]. NUCLEIC ACIDS RESEARCH, 2004, 32 (14) : 4358 - 4367
[8] APC/Fizzy-Related targets Aurora-A kinase for proteolysis
Castro, A
Arlot-Bonnemains, Y
Vigneron, S
Labbé, JC
Prigent, C
Lorca, T
[J]. EMBO REPORTS, 2002, 3 (05) : 457 - 462
[9] The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A
Castro, A
Vigneron, S
Bernis, C
Labbé, JC
Prigent, C
Lorca, T
[J]. EMBO REPORTS, 2002, 3 (12) : 1209 - 1214
[10] CREPIEUX P, 1994, CRIT REV ONCOGENESIS, V5, P615

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